VEGF-VEGFR Signals in Health and Disease.
VEGF-VEGFR Signals in Health and Disease.
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DOI：
10.4062/biomolther.2013.113
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发表时间：
2014-01
影响因子：
3.7
通讯作者：
Shibuya M
中科院分区：
文献类型：
--
作者：
Shibuya M
血管内皮生长因子（Vascular endothelial growth factor，VEGF）-血管内皮生长因子受体（Vascular endothelial growth factor receptor，VEGFR）系统不仅在生理性血管生成中起重要作用，而且在肿瘤等疾病的病理性血管生成中也起重要作用。基于这些发现，已经开发了多种抗血管生成药物，包括抗VEGF抗体和VEGFR/多受体激酶抑制剂，并批准用于临床使用。虽然这些药物的临床疗效已在癌症患者中得到明确证明，但它们尚未被证明能有效治愈癌症，这表明有必要进一步改进其设计。内源性VEGF抑制剂sFlt-1的异常表达已被证明参与多种疾病，如先兆子痫和老年黄斑变性。此外，最近已经分离出调节血管生成过程的各种因素。鉴于这种复杂性，深入研究VEGF信号和其他血管生成调控系统之间的相互关系，对于开发未来抑制血管生成成分疾病的策略将非常重要。
Vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) system has been shown to play central roles not only in physiological angiogenesis, but also in pathological angiogenesis in diseases such as cancer. Based on these findings, a variety of anti-angiogenic drugs, including anti-VEGF antibodies and VEGFR/multi-receptor kinase inhibitors have been developed and approved for the clinical use. While the clinical efficacy of these drugs has been clearly demonstrated in cancer patients, they have not been shown to be effective in curing cancer, suggesting that further improvement in their design is necessary. Abnormal expression of an endogenous VEGF-inhibitor sFlt-1 has been shown to be involved in a variety of diseases, such as preeclampsia and aged macular degeneration. In addition, various factors modulating angiogenic processes have been recently isolated. Given this complexity then, extensive studies on the interrelationship between VEGF signals and other angiogenesis-regulatory systems will be important for developing future strategies to suppress diseases with an angiogenic component.
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