Vascular endothelial growth factor vascular permeability factor produces nitric oxide-dependent hypotension - Evidence for a maintenance role in quiescent adult endothelium
Vascular endothelial growth factor vascular permeability factor produces nitric oxide-dependent hypotension - Evidence for a maintenance role in quiescent adult endothelium
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DOI：
10.1161/01.atv.17.11.2793
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发表时间：
1997-11-01
影响因子：
8.7
通讯作者：
Isner, JM
中科院分区：
文献类型：
--
作者：
Horowitz, JR;Rivard, A;Isner, JM
体外研究表明，血管内皮生长因子/血管通透性因子（VEGF/VPF）可能刺激内皮细胞释放一氧化氮（NO）。为了研究重组VEGF/VPF在体内的血流动力学影响，将重组人VEGF/VPF以500 μ g的剂量给药给麻醉（n=6）或清醒（n=5）的新西兰大白兔，以及麻醉后的饮食性高胆固醇血症兔（HC, n=7）。研究麻醉约克郡农场猪（无特定饲料预处理）在500 μ g静脉注射（IV; n=5）或冠状动脉内注射（IC; n=5） VEGF/VPF前后的情况。在麻醉正常家兔中，平均动脉压（MAP）下降20.5±1.4% (P
In vitro studies suggest that vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) may stimulate release of nitric oxide (NO) from endothelial cells. To investigate the hemodynamic consequences of recombinant VEGF/VPF administered in vivo, recombinant human VEGF/VPF was administered as a bolus dose of 500 mu g to anesthetized (n=6) or conscious (n=5) New Zealand White rabbits, as well as anesthetized rabbits with diet-induced hypercholesterolemia (HC; n=7). Anesthetized Yorkshire farm pigs (no specific dietary pretreatment) were studied before and after receiving 500 mu g intravenous (IV; n=5) or intracoronary (IC; n=5) VEGF/VPF. In anesthetized, normal rabbits, mean arterial pressure (MAP) fell by 20.5+/-1.4% (P