Heterotopic Ossification in Trauma
Heterotopic Ossification in Trauma
复制标题
DOI：
10.1016/j.ocl.2016.08.009
复制
发表时间：
2017-01-01
影响因子：
1.8
通讯作者：
Hartsock, Langdon A.
中科院分区：
文献类型：
--
作者：
Barfield, William R.;Holmes, Robert E.;Hartsock, Langdon A.
更好地了解异位骨化（HO）形成的生物学将导致治疗和预防模式，可以专门针对细胞水平。HO前体细胞和靶基因的早期鉴定可提供预后价值，指导个体化预防性治疗。更好地理解分子信号和蛋白质组学变异性将使外科医生能够个体化先发制人的治疗，以抑制炎症和HO的形成。小心的手术技术以避免肌肉损伤是重要的。作为预防措施，应清除受损的肌肉。止血和避免术后血肿可能会减少HO形成的机会。
Better understanding of the biology of heterotopic ossification (HO) formation will lead to treatment and prevention modalities that can be directed specifically at the cellular level. Early identification of HO precursor cells and target genes may provide prognostic value that guides individualized prophylactic treatment. Better understanding of molecular signaling and proteomics variability will allow surgeons to individualize preemptive treatment to suppress inflammation and formation of HO. Careful surgical technique to avoid muscle damage is important. Damaged muscle should be debrided as a prophylactic measure. Hemostasis and avoidance of a postoperative hematoma may decrease the chance of formation of HO.