Lewis acid-promoted coupling reactions of acid chlorides with organoaluminum and organozinc reagents
Lewis acid-promoted coupling reactions of acid chlorides with organoaluminum and organozinc reagents
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DOI：
10.1021/jo970244a
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发表时间：
1997-06-27
影响因子：
3.6
通讯作者：
Nakagawa, M
中科院分区：
文献类型：
--
作者：
Arisawa, M;Torisawa, Y;Nakagawa, M
描述了在 AlCl3（1 摩尔当量）存在下，通过酰氯与三烷基铝（1/3 摩尔当量）反应有效合成 α,β-不饱和酮。二烷基锌也很有用，并且比三烷基铝更容易制备。 RCOCl与R'AlCl2或R-2'AlCl反应以高产率得到R'COR，无需AlCl3。
An efficient synthesis of alpha,beta-unsaturated ketones by the reaction of acid chlorides with trialkylaluminum (1/3 mole equiv) in the presence of AlCl3 (1 mol equiv) is described. Dialkylzincs were also useful and are easier to prepare than trialkylaluminum. Reaction of RCOCl with R'AlCl2 or R-2'AlCl gave R'COR, without AlCl3, in high yield.