Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments
Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments
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DOI：
10.1016/j.talanta.2005.09.037
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发表时间：
2006-04-15
期刊：
影响因子：
6.1
通讯作者：
Barceló, D
中科院分区：
文献类型：
--
作者：
Hernando, MD;Mezcua, M;Barceló, D
环境中药物残留及其潜在的毒性作用已成为环境化学研究的新兴领域之一。药物残留物作为潜在污染物受到越来越多的关注，是因为它们往往具有与其他有害的外源物相似的物理化学行为，而其他有害的外源物是持久的或产生不利影响的。此外，受管制的污染物通常具有较长的环境半衰期，与之相反，其不断进入环境可能使其成为“伪持久性”。药物残留和/或其代谢物通常在环境中以微量水平检测到，但即使如此，低浓度水平（ng/L或μ g/L）也会引起毒性作用。特别是抗生素和类固醇，它们会引起天然细菌群体的耐药性或内分泌干扰效应。本文从文献资料出发，对药物残留的环境发生及生态风险评价进行了综述。风险商法（RQ）是一种评估废水、地表水和沉积物中最常见的药物的环境风险的新方法。(C) 2005 Elsevier B.V.版权所有
Pharmaceutical residues in the environment, and their potential toxic effects, have been recognized as one of the emerging research area in the environmental chemistry. The increasing attention, on pharmaceutical residues as potential pollutants, is due that they often have similar physico-chemical behaviour than other harmful xenobiotics which are persistent or produce adverse effects. In addition, by contrast with regulated pollutants, which often have longer environmental half-lives, its continuous introduction in the environment may make them "pseudopersistents".Pharmaceutical residues and/or their metabolites are usually detected in the environment at trace levels, but, even that, low concentration levels (ng/L or mu g/L) can induce to toxic effects. In particular, this is the case of antibiotics and steroids that cause resistance in natural bacterial populations or endocrine disruption effects.In this study, an overview of the environmental occurrence and ecological risk assessment of pharmaceutical residues is presented from literature data. Risk Quotient method (RQ) was applied as a novel approach to estimate the environmental risk of pharmaceuticals that are most frequently detected in wastewater effluents, surface waters and sediments. (C) 2005 Elsevier B.V. All rights reserved.