CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.
CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.
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DOI：
10.1016/j.cellimm.2008.05.007
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发表时间：
2008-05
影响因子：
4.3
通讯作者：
Lawrence, David A.
中科院分区：
文献类型：
--
作者：
Han, Guang Ming;O'Neil-Andersen, Nancy J.;Zurier, Robert B.;Lawrence, David A.
越来越多的证据表明，CD4+CD25High T调节性T细胞在控制和预防自身免疫中发挥着重要作用。矛盾的是，RA患者循环中的CD4+CD25High T细胞数量增加，然而，炎症仍在继续。对这些CD4+CD25High T细胞的进一步鉴定可能有助于更好地了解其潜在的机制。这些T细胞由CD_4+CD_(25)HighFoxP3+Treg细胞和活化的CD_4+CD_(25)HighFoxP3−效应细胞组成。此外，表达GITR的Treg细胞和效应T细胞明显增多，表达GITR-L的单核细胞明显增多。因此，尽管RA患者的CD4+CD25High T细胞数量增加，但抑制功能并没有增加，因为激活的效应性T细胞数量增加了。此外，RA患者GITR-GITR-L系统被激活，这可能导致Treg细胞的抑制活性降低和/或导致抵抗激活的效应T细胞对Treg细胞的抑制，从而导致RA患者的持续炎症。
Accumulating evidences support that CD4+CD25high T regulatory (Treg) cells play an essential role in controlling and preventing autoimmunity. Paradoxically, RA patients have elevated numbers of circulating CD4+CD25high T cells, however, the inflammation is still ongoing. Further identification of these CD4+CD25high T cells may contribute to a better understanding of underlying mechanisms. We show here that these CD4+CD25high T cells were composed of CD4+CD25highFoxP3+ Treg cells and activated CD4+CD25highFoxP3− effector cells. Moreover, there were significantly more Treg cells and effector T cells expressing GITR, and more monocytes expressing GITR-L. Thus, although RA patients have elevated numbers of CD4+CD25high T cells, the suppressive function is not increased, because of the increased number of activated effector T cells. In addition, the GITR-GITR-L system was activated in RA patients, which might lead to diminish suppressive activity of Treg cells and/or lead to resist to suppression of Treg cells by activated effector T cells, thus, contributing to the ongoing inflammation in RA patients.
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影响因子：
45.3
作者：
Cesana, GC;DeRaffele, G;Kaufman, HL
通讯作者：
Kaufman, HL
影响因子：
4.4
作者：
Ji, HB;Liao, GX;Terhorst, C
通讯作者：
Terhorst, C
影响因子：
27.4
作者：
Suarez, A.;Lopez, P.;Gutierrez, C.
通讯作者：
Gutierrez, C.
调节性T细胞在类风湿关节炎和抗TNFALPHA治疗中的逆转功能受损。
影响因子：
15.3
作者：
Ehrenstein, MR;Evans, JG;Singh, A;Moore, S;Warnes, G;Isenberg, DA;Mauri, C
通讯作者：
Mauri, C
影响因子：
8.6
作者：
Pillai, Vinodh;Ortega, Sterling B.;Karandikar, Nitin J.
通讯作者：
Karandikar, Nitin J.