Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence
Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence
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DOI：
10.1128/microbiolspec.mgm2-0007-2013
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发表时间：
2014-02-01
影响因子：
3.7
通讯作者：
Manganelli, Riccardo
中科院分区：
文献类型：
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作者：
Manganelli, Riccardo
快速适应不断变化的环境是微生物成功的关键之一。由于感染是一个动态过程，因此可以预测结核分枝杆菌的适应涉及其全球转录谱的持续调节，以响应人体内不断变化的环境。在过去的18年里，一些研究强调了sigma（s）因素在这一过程中的作用。这些是RNA聚合酶全酶的小的可互换的亚基，其是转录起始所需的并且决定启动子特异性。分枝结核病基因组编码13种蛋白质，其中一种-主要的s因子s A-是必需的。在其他12个S因子中，至少有6个是毒力所必需的。在这篇文章中，我们回顾了我们目前的知识，分枝杆菌的因素，他们的调节，复杂的机制，决定他们的调节，和他们的作用，在M。结核生理学和毒力。
Rapid adaptation to changing environments is one of the keys to the success of microorganisms. Since infection is a dynamic process, it is possible to predict that Mycobacterium tuberculosis adaptation involves continuous modulation of its global transcriptional profile in response to the changing environment found in the human body. In the last 18 years several studies have stressed the role of sigma (s) factors in this process. These are small interchangeable subunits of the RNA polymerase holoenzyme that are required for transcriptional initiation and that determine promoter specificity. The M. tuberculosis genome encodes 13 of these proteins, one of which-the principal s factor s A-is essential. Of the other 12 s factors, at least 6 are required for virulence. In this article we review our current knowledge of mycobacterial s factors, their regulons, the complex mechanisms determining their regulation, and their roles in M. tuberculosis physiology and virulence.