Dietary effects on drug metabolism by the mixed-function oxidase system.
Dietary effects on drug metabolism by the mixed-function oxidase system.
复制标题
饮食对混合功能氧化酶系统药物代谢的影响。
DOI：
10.1016/0163-7258(88)90102-7
复制
发表时间：
1988
影响因子：
13.5
通讯作者：
Yoo,JS
中科院分区：
文献类型：
--
作者：
Yang,CS;Yoo,JS
饮食和营养被广泛认为是药物新陈代谢的调节因素。这一主题在最近的几篇评论中都有讨论(Bidlack等人，1986；Hathcock，1985；Anderson等人，1985；Guengerich，1984)。饮食因素会影响药物在体内的吸收和分布，以及这些化合物的“I期”和“II期”代谢。到目前为止，氧化是I相代谢中最常见的途径，该反应是由细胞色素P-450依赖(P-450依赖)的酶系统催化的，通常被称为混合功能氧化酶(MFO)。在这篇综述中，我们将讨论饮食如何影响这一MFO系统和药物代谢。MFO酶在致癌物和环境化学物质的代谢激活中也很重要，因此本文包括了这些反应，尽管这些有毒化学物质不是药物。由于这一主题的复杂性，本文并不打算对现有文献进行详尽的回顾。相反，我们计划集中在饮食因素对药物代谢影响的分子基础上。通过这样的分析，我们希望勾勒出几个概念，这些概念将有助于解释现有的结果和规划未来的实验，以便更好地理解这一主题。
Diet and nutrition are widely recognized to be modulating factors in the metabolism of drugs. This topic has been discussed in several recent reviews (Bidlack et al., 1986; Hathcock, 1985; Anderson et al., 1985; Guengerich, 1984). Dietary factors can affect the absorption and distribution of drugs in the body as well as the'phase I'and'phase II'metabolism of these compounds. Oxygenation is by far the most common pathway in'phase I'metabolism and the reaction is catalyzed by a cytochrome P-450-dependent (P-450-dependent) enzyme system generally known as mixed-function oxidase (MFO). In this review, we shall discuss how diet affects this MFO system and drug metabolism. The MFO enzymes are also important in the metabolic activation of carcinogens and environmental chemicals, and therefore such reactions are included in this article although these toxic chemicals are not drugs. Because of the complexity of the topic, this article is not intended to be an exhaustive review of the existing literature. Instead, we plan to concentrate on the molecular basis of the effects of dietary factors on drug metabolism. Through such analysis, we hope to delineate several concepts that will be useful for interpreting existing results and for planning future experiments in order to gain a better understanding of this topic.