SEQUENTIAL CARDIORESPIRATORY PATTERNS OF ANESTHETIC INDUCTION WITH KETAMINE IN CRITICALLY ILL PATIENTS
SEQUENTIAL CARDIORESPIRATORY PATTERNS OF ANESTHETIC INDUCTION WITH KETAMINE IN CRITICALLY ILL PATIENTS
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DOI：
10.1097/00003246-198309000-00012
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发表时间：
1983-01-01
影响因子：
8.8
通讯作者：
SHOEMAKER, WC
中科院分区：
文献类型：
--
作者：
LIPPMANN, M;APPEL, PL;SHOEMAKER, WC
观察22例危重病人氯胺酮麻醉对血流动力学和氧转运的影响。在放置径动脉和肺动脉导管后，同时测量心输出量、血管内压、动脉和混合静脉气体、饱和度、pH和Hct；然后计算诱导前控制期的心呼吸值，并在15分钟的观察期内以频繁的间隔顺序计算心呼吸值。一般情况下，心率、心脏指数(CI)、动、静脉压、每搏功和氧输送(DO2)呈进行性增加，氧耗量(VO2)和氧摄取量(O2Ext)下降。总体而言，氯胺酮产生变力心脏反应，但这些反应并不一致；相对较小的比例出现了与低血容量和相关医疗条件有关的压力、流量和心肌功能下降。
Hemodynamic and O 2 transport effects of ketamine anesthesia were evaluated in 22 critically ill patients. After placement of radial and pulmonary artery catheters, simultaneous measurements were made of cardiac output, intravascular pressures, arterial and mixed venous gases, saturations, pH, and Hct; cardiorespiratory values then were calculated for a preinduction control period and sequentially at frequent intervals over a 15-min observation period. In general, there was an early progressive increase in HR, cardiac index (CI), arterial and venous pressures, stroke work, and O 2 delivery (Do 2); O 2 consumption (Vo 2) and O 2 extraction (O 2 Ext) decreased. In general, ketamine produced an inotropic cardiac response, but these responses were not uniform; a relatively small percentage had reduced pressures, flow, and reduced myocardial performance that were related to hypovolemia and associated medical conditions.