Hybrid reflection retrieval method for terahertz dielectric imaging of human bone.
Hybrid reflection retrieval method for terahertz dielectric imaging of human bone.
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DOI：
10.1364/boe.427648
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发表时间：
2021-08-01
影响因子：
3.4
通讯作者：
Navarro-Cía M
中科院分区：
文献类型：
--
作者：
Freer S;Sui C;Hanham SM;Grover LM;Navarro-Cía M
太赫兹成像与更成熟的红外和x射线技术一样，正以其自身的权利成为一种生物成像方式。然而，样品的高光谱、生物特征信息的提取受到实验挑战的限制。太赫兹时域光谱反射测量需要高度精确的对准，并且受样品厚度的限制。在这项工作中，开发了一种新的基于Kramers-Kronig和fabry - p郁闷的混合算法来克服这些挑战。虽然它的应用是通过玻璃支撑的人骨切片的介质检索来证明转移性缺陷或骨质疏松症的前瞻性特征，但该算法的通用性为其在生物材料方面提供了更广泛的应用。
Terahertz imaging is becoming a biological imaging modality in its own right, alongside the more mature infrared and X-ray techniques. Nevertheless, extraction of hyperspectral, biometric information of samples is limited by experimental challenges. Terahertz time domain spectroscopy reflection measurements demand highly precise alignment and suffer from limitations of the sample thickness. In this work, a novel hybrid Kramers-Kronig and Fabry-Pérot based algorithm has been developed to overcome these challenges. While its application is demonstrated through dielectric retrieval of glass-backed human bone slices for prospective characterisation of metastatic defects or osteoporosis, the generality of the algorithm offers itself to wider application towards biological materials.