Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)
Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)
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DOI：
10.1136/oem.2009.048785
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发表时间：
2010-05-01
影响因子：
4.9
通讯作者：
Weiland, Stephan K.
中科院分区：
文献类型：
--
作者：
Anderson, H. Ross;Ruggles, Ruth;Weiland, Stephan K.
目的探讨环境颗粒物对儿童哮喘、鼻结膜炎和湿疹患病率的影响。方法将儿童哮喘、鼻结膜炎和湿疹的患病率与国际儿童哮喘和过敏性疾病研究(ISAC)第一阶段得到的儿童哮喘、鼻结膜炎和湿疹的患病率进行匹配，并与世界银行模型得到的城市居民区PM10进行比较。根据人均国民生产总值和国家内部的分组情况，使用二项回归方法对相关性进行了调查。对于有一个以上中心的国家，进行了两个阶段的荟萃分析。结果获得了51个国家和地区105个艾萨克中心的城市PM10年浓度。在控制人均国民生产总值后，PM10与各种结果之间存在微弱的负相关。对于13-14岁的重度喘息，PM10增加10微克/米(3)的OR为0.92(95%CI为0.84比1.00)。在拥有一个以上中心的24个国家中，对国内协会的大多数简要估计都是微弱的积极。对于13-14岁的严重喘息，PM10每增加10微克/立方米的汇总OR为1.01(0.92比1.10)。这一结果与已发表的多中心研究得出的汇总OR为0.99(0.91到1.06)接近。结论对城市水平颗粒物的建模估计是对个人暴露于环境空气污染物的不准确和不完整的估计。然而，我们的结果与之前的多中心研究结果一起表明，无论是在国家内部还是在国家之间，城市背景PM10与儿童哮喘、鼻结膜炎或湿疹的患病率几乎或没有关联。
Objectives To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema.Methods Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM10 obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies.Results Annual concentrations of PM10 at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM10 and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 mu g/m(3) increase in PM10 was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 mu g/m(3) increase in PM10 was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies.Conclusions Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM10 has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.