STRUCTURAL REQUIREMENTS OF STEROLS FOR INTERACTION WITH LECITHIN AT AIR-WATER INTERFACE
STRUCTURAL REQUIREMENTS OF STEROLS FOR INTERACTION WITH LECITHIN AT AIR-WATER INTERFACE
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DOI：
10.1016/0005-2736(72)90030-2
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发表时间：
1972-01-01
期刊：
影响因子：
--
通讯作者：
BRUCKDORFER, KR
中科院分区：
文献类型：
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作者：
DEMEL, RA;VANDEENE.LL;BRUCKDORFER, KR
1.1. 研究了3β-、3α-羟基甾醇和酮类固醇单分子膜的力面积特性。3β-羟基甾醇胆固醇、胆甾醇、胆甾醇、7-脱氢胆固醇和b -去甲胆固醇在气-水界面垂直取向，并表现出较高的崩溃压力。麦角甾醇、豆甾醇和雄甾-3β-醇在高压下表现出类似的行为，但崩溃压力降低。花椰菜结构的coprostanol显示每个分子的面积增加。与3β-羟基甾醇相比，3α-羟基甾醇（表胆固醇和雄甾-3α-醇）显示出明显降低的崩溃压力。所有的酮类固醇都显示出每个分子的高面积。力-面积曲线温度效应较小。18:1/18:0卵磷脂与甾醇的相互作用依赖于：(a)平面甾醇核，(b) 3β-羟基，(c)完整侧链。除3 - β-羟基甾醇外，3α-羟基甾醇和酮类固醇也具有一定的缩合作用。然而，每个分子的最小面积只能用3β-羟基甾醇来实现。磷脂和甾醇在单层中的相互作用受多种因素的影响，包括范德华相互作用，但3β-羟基与环境之间的氢键也被认为是重要的。
1.1. The force area characteristics of monolayers of 3β-, 3α-hydroxysterols and ketosteroids have been studied.2.2. The 3β-hydroxysterols cholesterol, cholestanol, lathosterol, 7-dehydrocholesterol, and B-norcholesterol are perpendicularly oriented at the air-water interface and show high collapse pressures. Ergosterol, stigmasterol, and androstan-3β-ol demonstrate a similar behavior at high pressures, but the collapse pressure is reduced. Thecis-structured coprostanol shows an increased area per molecule. 3α-Hydroxysterols (epicholesterol and androstan-3α-ol) reveal strongly reduced collapse pressures when compared with the respective 3β-hydroxysterols. All ketosteroids show high areas per molecule.3.3. The force-area curves show little temperature effect.4.4. The interaction of 18:1/18:0 lecithin with sterols is dependent on: (a) planar sterol nucleus, (b) 3β-hydroxy group, (c) intact side chain.5.5. Besides 3β-hydroxysterols, 3α-hydroxysterols and ketosteroids can also show some condensation effect. However, minimal area per molecule can be achieved only with 3β-hydroxysterols.6.6. The interaction of lecithin and sterol in monolayers is governed by a number of factors including van der Waal's interactions, but also hydrogen bonding between the 3β-hydroxy group and environment is considered to be important.