Iontophoresis: a potential emergence of a transdermal drug delivery system.
Iontophoresis: a potential emergence of a transdermal drug delivery system.
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DOI：
10.3797/scipharm.1108-20
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发表时间：
2012-01
影响因子：
2.5
通讯作者：
Mishra DK
中科院分区：
文献类型：
--
作者：
Dhote V;Bhatnagar P;Mishra PK;Mahajan SC;Mishra DK
在过去的十年中，通过皮肤将药物递送到体循环中引起了很多关注。透皮治疗系统提出了活性成分通过皮肤的控制释放，并以预测的方式进入体循环。通过这些系统给药的药物可以逃脱首过代谢，并保持类似于连续静脉输注长达数天的稳态情况。然而，皮肤的优异的不渗透性为通过利用离子电渗疗法的概念成功递送药物分子提供了最大的挑战。本文综述了离子导入给药系统的原理、最新进展以及影响离子导入给药系统的因素。该输送系统利用电流作为离子和非离子药物渗透的驱动力。使用该技术的原理是可逆地改变皮肤的屏障特性，这可能会改善蛋白质、肽和其他大分子等药物的渗透，以增加高分子量化合物的全身递送，同时控制输入动力学和最小化受试者间的差异。虽然离子电渗疗法似乎是一个理想的候选人，以克服与离子药物的输送相关的限制，这种技术的进一步外推是必不可少的转化效用和大规模的人类应用。
The delivery of drugs into systemic circulation via skin has generated much attention during the last decade. Transdermal therapeutic systems propound controlled release of active ingredients through the skin and into the systemic circulation in a predictive manner. Drugs administered through these systems escape first-pass metabolism and maintain a steady state scenario similar to a continuous intravenous infusion for up to several days. However, the excellent impervious nature of the skin offers the greatest challenge for successful delivery of drug molecules by utilizing the concepts of iontophoresis. The present review deals with the principles and the recent innovations in the field of iontophoretic drug delivery system together with factors affecting the system. This delivery system utilizes electric current as a driving force for permeation of ionic and non-ionic medications. The rationale behind using this technique is to reversibly alter the barrier properties of skin, which could possibly improve the penetration of drugs such as proteins, peptides and other macromolecules to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability. Although iontophoresis seems to be an ideal candidate to overcome the limitations associated with the delivery of ionic drugs, further extrapolation of this technique is imperative for translational utility and mass human application.