Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component
Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component
复制标题
放化疗对原发性食管腺鳞癌有效，但对转移性腺癌无效
DOI：
10.11405/nisshoshi.112.278
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Takehara T.
中科院分区：
文献类型：
--
作者：
Nozaki Y;Nishida T;Hori Y;Shinzaki S;Kato M;Yakushijin T;Iijima H;Tsujii M;Morii E;Takehara T.
一名62岁的男子被转介到我们的医院吞咽困难。血液检查显示血清CA 19 -9水平显著升高，但CEA和SCC水平正常。影像学检查发现胸段食管癌伴肺和骨转移，随后的原发性食管肿瘤内镜活检标本显示为低分化鳞状细胞癌。患者接受姑息性放化疗，但由于多发性转移瘤进展和血清CA 19 -9水平升高而死亡。尸检发现腺癌在多个转移灶，虽然鳞状成分已消失的原发性和转移性病变。因此，我们得出结论，腺鳞癌的腺癌成分是化疗和放疗难治的。
A 62-year-old man was referred to our hospital with dysphagia. Blood examination revealed significantly elevated serum CA19-9 levels but normal CEA and SCC levels. Imaging uncovered thoracic esophageal cancer with lung and bone metastasis, and subsequent endoscopic biopsy specimens of the primary esophageal tumor showed poorly differentiated squamous cell carcinoma. The patient underwent palliative chemoradiotherapy, but died due to progression of multiple metastases and increasing serum CA19-9 levels. Autopsy revealed adenocarcinoma in multiple metastatic foci, although the squamous component had disappeared in the primary and metastatic lesions. Therefore, we concluded that the adenocarcinoma component of adenosquamous cell carcinoma was refractory to chemoradiotherapy.