Evaluation of IL-2, IL-10, IL-4 and γ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV
Evaluation of IL-2, IL-10, IL-4 and γ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV
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DOI：
10.3855/jidc.10919
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发表时间：
2019-05-01
影响因子：
1.9
通讯作者：
Porksheyan, Kristina
中科院分区：
文献类型：
--
作者：
Azatyan, Vahe;Yessayan, Lazar;Porksheyan, Kristina
简介：在炎症性牙周炎（IP）发作期间，口腔液细胞因子水平可能会发生很大变化，特别是在丙型肝炎病毒（HCV），B肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）的人群中。我们的研究的目的是评估水平的口服细胞因子在发病的IP之间的HCV，HBV和HIV阴性和阳性的个人，以评估当地的免疫状态，在这些infections.Methodology：这是一个病例对照研究与3组病毒感染的个人和对照组。结果：HCV感染45例（51.7%），HBV感染18例（20.7%），HIV感染24例（27.6%）。对于IL-2，与对照组相比，所有组均获得显著差异-2.83; HBV-31.1（p < 0.001），HCV-25.99（p < 0.001）和HIV-24.57（p < 0.001）。对于IL-10，在对照组-0.94与HCV-3.63（p = 0.027）、HBV-8.38（15.51）组之间观察到显著差异（p < 0.001）。与HCV 0.2（p < 0.001）和HIV 0.21（p = 0.037）组相比，对照组中的IL-4显著更高14.29。我们考虑年龄作为可能的混杂因素的校正分析显示，与对照组相比，所有组中只有IL-2存在显著差异：对照组vs HCV组（p = 0.001）;对照vs HBV（p = 0.024）;对照组vs HIV组（p = 0.004）。结论：当比较患有HCV、HBV和HIV的个体与非病毒个体的口腔流体细胞因子时，IL-2的显著差异的证据更明显。IL-2水平在所有3组中均显著高于非病毒组，即使年龄是混杂因素。
Introduction: Oral fluid cytokine levels can vary considerably during the onset of Inflammatory Periodontitis (IP) especially in people with hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Aim of our study was to evaluate levels of oral cytokines during the onset of IP among HCV, HBV and HIV negative and positive individuals in order to evaluate local immunity state during these infections.Methodology: This was a case control study with 3 groups of virally infected individuals and control group. All had IP including control group.Results: 45 patients (51.7%) had HCV, 18 (20.7%) HBV and 24 (27.6%) HIV. For IL-2 we received significant difference for all groups compared with control -2.83; HBV-31.1 (p < 0.001), HCV-25.99 (p < 0.001) and HIV-24.57 (p < 0.001). For IL-10 significant difference was observed between control -0.94 and HCV-3.63 (p = 0.027), HBV-8.38 (15.51) groups (p < 0.001). IL-4 was significantly higher in control group 14.29 compared to HCV 0.2 (p < 0.001) and HIV 0.21 (p = 0.037) group. The adjusted analysis where we consider age as possible confounder revealed that only IL-2 significantly differs for all groups compared with control group: control vs HCV (p = 0.001); control vs HBV (p = 0.024); control vs HIV (p = 0.004).Conclusions: Evidence for significant differences when comparing oral fluid cytokines of individuals with HCV, HBV and HIV with non-viral individuals was more obvious for IL-2. IL-2 levels were significantly higher in all 3 groups vs non-viral group even when age is confounder.