Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers:: A functional magnetic resonance imaging study
Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers:: A functional magnetic resonance imaging study
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DOI：
10.1016/j.biopsych.2005.04.028
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发表时间：
2005-09-15
影响因子：
10.6
通讯作者：
Walton, RT
中科院分区：
文献类型：
--
作者：
David, SP;Munafò, MR;Walton, RT
背景收敛的证据，从几个理论的发展，吸烟相关的环境刺激的激励敏感化表明，腹侧纹状体在处理吸烟相关的线索reactivity.Methods：26名健康的右利手志愿者（14名吸烟者和12名不吸烟的对照）进行了功能磁共振成像（fMRI），在此期间，中性和吸烟相关的图像。在腹侧纹状体/中脑核（VS/NAc）内进行感兴趣区分析，以对比吸烟相关（SR）和非吸烟相关中性（N）线索。使用全脑校正的Z阈值，在吸烟者的内侧眶额皮质、上级额回、前扣带回皮质和后梭状回以及使用未校正的Z统计（吸烟者Z = 3.2）的腹侧VS/NAc中观察到SR与N线索的组激活，但在非吸烟者中未观察到。感兴趣的区域内腹侧VS/NAc的信号变化的分析表明，SR与N的线索在吸烟者比controls.Conclusions的激活显着更大：这是第一次演示更大的VS/NAc激活吸烟成瘾的吸烟者比非吸烟者提出吸烟相关的线索，使用功能磁共振成像。吸烟者，但不是控制，表现出激活SR与N线索在一个分布式的奖励信号网络与引用其他药物滥用的反应性研究一致。
Background Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity.Methods: Twenty-six healthy right-handed volunteers (14 smokers and 12 nonsmoking controls) underwent functional magnetic resonance imaging (fMRI) during which neutral and smoking-related images were presented. Region of interest analyses were performed within the ventral striatum/nucleus accumbens (VS/NAc)for the contrast between smoking-related (SR) and nonsmoking related neutral (N) cues.Results. Group activation for SR versus N cues was observed in smokers but not in nonsmokers in medial orbitofrontal cortex, superior frontal gyrus, anterior cingulate cortex, and posterior fusiform gyrus using whole-brain corrected Z thresholds and in the ventral VS/NAc using uncorrected Z-statistics (smokers Z = 3.2). Region of interest analysis of signal change within ventral VS/NAc demonstrated significantly greater activation to SR versus N cues in smokers than controls.Conclusions: This is the first demonstration of greater VS/NAc activation in addicted smokers than nonsmokers presented with smoking-related cues using fMRI. Smokers, but not controls, demonstrated activation to SR versus N cues in a distributed reward signaling network consistent with cite reactivity studies of other drugs of abuse.