Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection.
Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection.
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CXCL10 rs1439490在血清阴性隐匿性丙型肝炎病毒感染中的调控多态性
DOI：
10.3748/wjg.v24.i20.2191
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发表时间：
2018-05-28
影响因子：
4.3
通讯作者：
Wang JB
中科院分区：
文献类型：
--
作者：
Wang X;Wang S;Liu ZH;Qi WQ;Zhang Q;Zhang YG;Sun DR;Xu Y;Wang HG;Li ZX;Cong XL;Zhao P;Zhou CY;Wang JB
目的 研究单核苷酸多态性 CXCL10 rs1439490 与血清阴性隐匿性丙型肝炎病毒 (HCV) 感染 (OCI) 之间的关系。 2012年至2016年，中国东北地区5个肝脏中心诊断出103例血清阴性OCI病例和155例血清阳性慢性HCV感染（CHC）病例。对CXCL10 rs1439490、rs1440802和IL-28B rs12979860进行测序分析。通过ELISA测定血清CXCL10。通过定量PCR和免疫组织化学半定量评分测定肝内CXCL10。根据METAVIR系统对肝脏坏死炎症和纤维化进行评分。 CXCL10 rs1439490 G/G 在 OCI 患者 (n = 93/103; 90.3%) 中比在 CHC 患者中更常见 (n = 116/155; 74.8%; P = 0.008)。 OCI 患者的血清 CXCL10 水平低于 CHC 患者（192.91 ± 46.50 pg/mL vs 354.78 ± 102.91 pg/mL，P < 0.0001）。在IL-28B rs12979860 C/C患者中，与非G/G患者相比，具有rs1439490 G/G的OCI患者的血清和肝脏CXCL10水平较低，肝脏坏死炎症和纤维化水平较低。 OCI患者经Peg干扰素治疗后丙氨酸转氨酶正常化率高于CHC患者（P < 0.05），且血清CXCL10显着降低（P < 0.0001）。 8例OCI患者治疗后肝脏坏死性炎症和纤维化得到缓解。多变量分析表明rs1439490 G/G显着影响HCV感染中OCI的发生(OR = 0.31, 95%CI: 0.15-0.66, P = 0.002)。 CXCL10 rs1439490 G/G 与 HCV 感染和抗病毒结果中的 OCI 呈正相关。
To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus (HCV) infection (OCI). One hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection (CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system. CXCL10 rs1439490 G/G was more prevalent in OCI patients (n = 93/103; 90.3%) than in CHC patients (n = 116/155; 74.8%; P = 0.008). OCI patients had lower serum CXCL10 levels than CHC patients (192.91 ± 46.50 pg/mL vs 354.78 ± 102.91 pg/mL, P < 0.0001). Of IL-28B rs12979860 C/C patients, OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peg-interferon treatment than CHC patients (P < 0.05) and serum CXCL10 decreased significantly (P < 0.0001). Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment. Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection (OR = 0.31, 95%CI: 0.15-0.66, P = 0.002). CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.
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