Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point
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DOI：
10.1053/j.semdp.2017.04.003
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发表时间：
2017-07-01
影响因子：
2.3
通讯作者：
Quintanilla-Martinez, Leticia
中科院分区：
文献类型：
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作者：
Linke-Serinsoez, Ebru;Fend, Falko;Quintanilla-Martinez, Leticia
自35年前HIV流行开始以来，已经广泛研究了Epstein巴尔病毒（EBV）和卡波西肉瘤疱疹病毒（KSHV）对人类免疫缺陷病毒（HIV）背景下发生的特定类型恶性淋巴瘤发展的贡献。1996年，高效抗逆转录病毒疗法（HAART）的引入极大地改变了艾滋病毒相关恶性肿瘤的发病率。然而，恶性淋巴瘤仍然是在HIV感染者中观察到的主要恶性肿瘤，并且是癌症相关死亡的最常见原因。在HIV感染的情况下，主要的B细胞淋巴瘤的共同特征是肿瘤细胞的频繁浆细胞样形态、晚期、侵袭性疾病和频繁的淋巴结受累。在这篇文章中，我们回顾了各种EB病毒相关的淋巴瘤的概念和定义的演变，包括弥漫性大B细胞淋巴瘤，伯基特淋巴瘤，经典霍奇金淋巴瘤，浆母细胞淋巴瘤和原发性渗出性淋巴瘤。还探讨了有关这些恶性肿瘤发病机制的现有知识、HIV和EB病毒共感染在某些HIV相关淋巴瘤发展中的相互作用，以及表明HIV可能在淋巴瘤发生中发挥直接作用的新范式。(C)2017爱思唯尔公司All rights reserved.
The contribution of Epstein Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV) to the development of specific types of malignant lymphomas occurring in the human immunodeficiency virus (HIV) setting has been extensively studied since the beginning of the HIV epidemic 35 years ago. The introduction of highly active antiretroviral therapies (HAART) in 1996 has changed dramatically the incidence of HIV related malignancies. Nevertheless, malignant lymphomas continue to be the major group of malignances observed in HIV infected individuals, and the most common cause of cancer related-deaths. Common features of the predominant B-cell lymphomas in the HIV' setting are the frequent plasmacytoid morphology of the neoplastic cells, advanced stage, aggressive disease and frequent extranodal involvement. In this article, we review the evolving concepts and definitions of the various EBV-assodated lymphomas in HIV+ patients, including diffuse large B-cell lymphoma, Burkitt lymphoma, classical Hodgkin lymphoma, plasmablastic lymphoma and primary effusion lymphoma. The current knowledge regarding the pathogenesis of these malignancies, the interplay between HIV and EBV co infection in the development of certain HIV related lymphomas, and the emerging paradigm that suggests that HIV may play a direct role in lymphomagenesis are explored as well. (C) 2017 Elsevier Inc. All rights reserved.