Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss
复制标题
发炎的成牙本质细胞凋亡增加与 CD47 丢失相关
DOI：
10.1177/0022034516633639
复制
发表时间：
2016-06-01
影响因子：
7.6
通讯作者：
Zhang, L.
中科院分区：
文献类型：
--
作者：
Wang, H. S.;Pei, F.;Zhang, L.
Survival of odontoblasts during infection and inflammation determines prognosis of the dental pulp. CD47 is a "self"-label surface marker on viable cells. The aim of the present study is to investigate the interaction between CD47, autophagy, and apoptosis in inflamed human dental pulp and lipopolysaccharide (LPS)-treated mDPC6T cells. We identified activation of autophagy and apoptosis in the odontoblasts due to inflammation of the human dental pulp. Furthermore, downregulation of CD47 correlated with increased autophagy and apoptosis in dental pulp of the patients afflicted with either caries and/or pulpitis. We also detected colocalization of CD47 and LC3 in the inflamed odontoblasts. In addition, functional study indicated that loss of CD47 activates autophagy and increases apoptosis, indicating that CD47 plays a key role in the LPS-induced autophagy and apoptosis of odontoblasts.
