Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept
Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept
复制标题
人类胚胎胸骨柄的形态发生：一个新概念
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ji Hyun Kim
中科院分区：
文献类型：
--
作者：
J. Rodríguez;S. Verdugo‐López;J. M. Garrido;G. Murakami;Ji Hyun Kim
为了重新审视许多关于胸骨柄胎儿发育的理论，我们检查了25例妊娠6-9周的中期胎儿。手骨发育的初始阶段的特点是锁骨间的间充质与锁骨的发育是连续的。由于发生软骨内骨化的锁骨部分起源于神经嵴，因此锁骨间充质似乎是同一来源。胸骨带可能起源于外侧板，局限于成对胸壁的肋骨前端。锁骨间充质向尾侧和外侧延伸至第一肋骨的前端，因此锁骨间充质扩张成肋锁间充质。然后，原始手骨由胸锁关节及其相关韧带界定，所有这些韧带都是由锁骨间和肋锁间充质发育而来的。尽管第一肋骨附着于肋锁间质，但前者是波形蛋白阴性的，而后者是阳性的间质。此后不久，胸骨带的小上端整合到肋锁间充质中，形成原始的手骨。舌骨下肌及其供应神经与锁骨间或肋锁间间充质保持密切的地形关系，而胸大肌则与胸骨带保持附着。因此，胸骨柄似乎在神经嵴、侧板和体节的衍生物之间的交界区以复杂的方式发育。Anat Rec，2013.© 2012 Wiley Periodicals，Inc.
To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid‐term fetuses at 6–9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentin‐negative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.
影响因子：
2.7
作者：
Brewer, S;Williams, T
通讯作者：
Williams, T
影响因子：
2.7
作者：
Manley, NR;Barrow, JR;Capecchi, MR
通讯作者：
Capecchi, MR