DURATION OF THE QT INTERVAL AND TOTAL AND CARDIOVASCULAR MORTALITY IN HEALTHY-PERSONS (THE FRAMINGHAM HEART-STUDY EXPERIENCE)
DURATION OF THE QT INTERVAL AND TOTAL AND CARDIOVASCULAR MORTALITY IN HEALTHY-PERSONS (THE FRAMINGHAM HEART-STUDY EXPERIENCE)
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DOI：
10.1016/0002-9149(91)90099-7
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发表时间：
1991-01-01
影响因子：
2.8
通讯作者：
LEVY, D
中科院分区：
文献类型：
--
作者：
GOLDBERG, RJ;BENGTSON, J;LEVY, D
对5，125例Frachial Heart研究原始受试者的基线心电图进行了测量，以检查30年随访期间心率校正的QT间期（QTc）与总死亡率、心源性猝死和冠状动脉疾病死亡风险的关系。 研究了QTc（秒）小于或等于0.36、0.36至0.38、0.39至0.40、0.41至0.43和大于或等于0.44的昆泰与这些结局的关系。 根据QTc，总死亡率、心源性猝死或冠状动脉疾病死亡的风险无显著差异。 在使用多元回归分析控制几个潜在混杂特征（包括年龄、性别、吸烟、血清总胆固醇、收缩压和相对体重）后，在所有研究人员和2种性别中观察到QTc与这3种结局之间同样缺乏显著相关性。 本研究的结果未能证明基线QTc与总体死亡率之间的相关性，以及在一个基于人群的基本健康人群队列中因突发心脏事件或冠状动脉疾病导致的死亡，这些人群中病理形式的QTc延长并不常见。
The baseline electrocardiograms of 5,125 original subjects of the Framingham Heart Study were measured to examine the relation of the QT interval corrected for heart rate (QTc) t risk of total mortality, sudden cardiac death, and death due to coronary artery disease over a 30-year follow-up period. Quintiles of QTc (seconds) less-than-or-equal-to 0.36, 0.36 to 0.38, 0.39 to 0.40, 0.41 to 0.43 and greater-than-or-equal-to 0.44 were studied in relation to these outcomes. There were no significant differences in the risk of total mortality, sudden cardiac death or death due to coronary artery disease according to QTc. A similar lack of significant association between QTc and these 3 outcomes was observed among all persons studied and in the 2 sexes after using a multiple regression analysis to control for several potentially confounding characteristics including age, gender, cigarette smoking, serum total cholesterol, systolic systemic blood pressure and Framingham relative weight. The results of this study fail to demonstrate an association between baseline QTc and overall mortality, and deaths due to sudden cardiac events or coronary artery disease in a large population-based cohort of essentially healthy persons in whom pathologic forms of QTc prolongation are uncommon.