Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma
Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma
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DOI：
10.1167/iovs.13-13245
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Burgoyne, Claude F.
中科院分区：
文献类型：
--
作者：
He, Lin;Yang, Hongli;Burgoyne, Claude F.
目的。检测8只实验性青光眼(EG)的光谱域光学相干断层扫描(SDOCT)视神经头(ONH)变化是否先于共聚焦激光扫描断层扫描(CSLT)视神经纤维层(RNFL)、扫描激光视野(SLP)和多焦视网膜电图(MfERG)的变化。研究了11个SDOCT神经和结缔组织、CSLT表面、SDOCT RNFL、SLP和mfERG参数在对照组和实验组的发病定义。结果：激光后最大眼压：实验组为18~42 mm Hg，对照组为12~20 mm Hg。对于基于事件和趋势的分析，使用SDOCT在ONH神经和结缔组织中最早和最频繁地实现起始集，使用CSLT在ONH表面实现起始集。在大多数EG眼中，SDOCT ONH神经和结缔组织参数变化先于或同时发生CSLT ONH表面变化。在猴子实验性青光眼中，SDOCT和SLP测量RNFL厚度以及mfERG测量视功能的发病率相似，但发生在SDOCT ONH和CSLT表面变化的时间晚于SDOCT ONH和CSLT表面变化，且较少。结论在猴子实验性青光眼中，SDOCT ONH变化检测通常先于或与CSLT ONH表面变化检测一致，并一致先于RNFLT、SLP和mfERG变化检测。
PURPOSE. We determined if the detection of spectral-domain optical coherence tomography (SDOCT) optic nerve head (ONH) change precedes the detection of confocal scanning laser tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), scanning laser perimetry (SLP), and multifocal electroretinography (mfERG) change in eight experimental glaucoma (EG) eyes.METHODS. Both eyes from eight monkeys were tested at least three times at baseline, and then every 2 weeks following laser-induced chronic unilateral IOP elevation. Event and trend-based definitions of onset in the control and EG eyes for 11 SDOCT neural and connective tissue, CSLT surface, SDOCT RNFL, SLP, and mfERG parameters were explored. The frequency and timing of onset for each parameter were compared using a logrank test.RESULTS. Maximum post-laser IOP was 18 to 42 mm Hg in the EG eyes and 12 to 20 mm Hg in the control eyes. For event-and trend-based analyses, onsets were achieved earliest and most frequently within the ONH neural and connective tissues using SDOCT, and at the ONH surface using CSLT. SDOCT ONH neural and connective tissue parameter change preceded or coincided with CSLT ONH surface change in most EG eyes. The SDOCT and SLP measures of RNFL thickness, and mfERG measures of visual function demonstrated similar onset rates, but occurred later than SDOCT ONH and CSLT surface change, and in fewer eyes.CONCLUSIONS. SDOCT ONH change detection commonly precedes or coincides with CSLT ONH surface change detection, and consistently precedes RNFLT, SLP, and mfERG change detection in monkey experimental glaucoma.