Association of Blood Trace Elements Levels with Cardiovascular Disease in US Adults: a Cross-Sectional Study from the National Health and Nutrition Examination Survey 2011-2016
Association of Blood Trace Elements Levels with Cardiovascular Disease in US Adults: a Cross-Sectional Study from the National Health and Nutrition Examination Survey 2011-2016
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DOI：
10.1007/s12011-023-03913-8
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发表时间：
2023-10-28
影响因子：
3.9
通讯作者：
Li，Xinli
中科院分区：
文献类型：
--
作者：
Guo，Qixin;Cai，Jingshan;Li，Xinli
我们的目的是探索微量元素与心血管疾病（CVD）及其类型之间的整体关联。共纳入了2011-2016年全国健康与营养检查调查的5101名参与者的血液样本。从移动的筛查中心进行的实验室检查中收集生化数据。在评估线性后，加权逻辑回归估计了微量元素与各种心血管疾病类型之间的关联。加权分位数和（WQS）回归和基于分位数的g计算（Qgcomp）评估生物微量元素和CVD类型之间的整体关系。在充分调整混杂因素后，高硒浓度的第二、第三和第四分位数对应的总体CVD发病率的比值比为0.711（95%CI，0.529- 0.956，p = 0.024）、0.734（95%CI，0.546- 0.987，p = 0.041）和0.738（95%CI，0.554- 0.983，p = 0.038）。此外，铜（Cu）浓度的增加与中风（95%CI，1.012- 1.094，p = 0.01）、心力衰竭（95%CI，1.001- 1.095，p = 0.046）和心脏病发作（95%CI，1.001- 1.083，p = 0.046）的风险增加相关。随着体内微量元素浓度的增加，Cu与CVD患病率呈显著正相关。另一方面，硒和锌与CVD患病率呈负相关。硒与心血管疾病之间存在非线性关系，适量摄入硒可降低心血管疾病的发病风险。Cu水平与CVD风险呈正相关。然而，前瞻性队列研究有必要确认微量营养素对CVD及其类型的因果关系。
We aimed to explore the overall association between trace elements and cardiovascular disease (CVD) and its types in humans. A total of 5101 participants’ blood samples from the 2011–2016 National Health and Nutrition Examination Survey were included. Biochemical data were collected from laboratory tests conducted at mobile screening centers. After assessing linearity, weighted logistic regression estimated the association between trace elements and various CVD types. Weighted quantile sum (WQS) regression and quantile-based g-computation (Qgcomp) evaluated the overall relationship between biological trace elements and CVD types. After fully adjusting for confounding factors, the odds ratios of overall CVD morbidity corresponding to the second, third, and fourth quartiles of higher selenium (Se) concentration were 0.711 (95% CI, 0.529–0.956,p= 0.024), 0.734 (95% CI, 0.546–0.987,p= 0.041), and 0.738 (95% CI, 0.554–0.983,p= 0.038), respectively. Moreover, an increase in the concentration of copper (Cu) was associated with an increased risk of stroke (95% CI, 1.012–1.094,p= 0.01), heart failure (95% CI, 1.001–1.095,p= 0.046), and heart attack (95% CI, 1.001–1.083,p= 0.046). As the concentration of trace elements in the body increased, there was a significant positive association between Cu and CVD prevalence. On the other hand, Se and zinc were negatively associated with CVD prevalence. A nonlinear relationship between Se and CVD was found, and an appropriate Se intake may reduce the risk of CVD. Cu levels positively correlated with CVD risk. However, prospective cohort studies are warranted to confirm the causal effects of the micronutrients on CVD and its types.