Is Low Testosterone Concentration a Risk Factor for Metabolic Syndrome in Healthy Middle-aged Men?
Is Low Testosterone Concentration a Risk Factor for Metabolic Syndrome in Healthy Middle-aged Men?
复制标题
DOI：
10.1016/j.urology.2013.06.023
复制
发表时间：
2013-10-01
期刊：
影响因子：
2.1
通讯作者：
Nonomura, Norio
中科院分区：
文献类型：
--
作者：
Tsujimura, Akira;Miyagawa, Yasushi;Nonomura, Norio
目的针对中年男性代谢综合征(MS)的直接危险因素尚未得到充分研究的现状，通过测定血清总睾酮(TT)水平，并对几种代谢因素进行评估，以明确血清睾酮水平降低作为代谢综合征(MS)危险因素的可能性。对物理和实验室变量进行了评估。结果1150例男性血清TT水平平均(+/-)为5.4+/-1.7 ng/mL，按日本标准分为MS组92例(8.0%)。在年龄调整的分析中，较高的血清TT水平独立地与较低的MS风险相关(优势比，每减少一次标准差TT，2.3；95%可信区间[CI]，1.7-2.9)。与TT的最高五分位数相比，前五分位数的ORS分别为15.1(95%CI，4.6~50.0)、8.8(95%CI，2.6~29.9)、5.8(95%CI，1.7~20.5)和5.0(95%CI，1.4~17.9)。年龄调整OR值为腰围1.8(95%CI，1.5~2.3)、血脂异常1.6(95%CI，1.1~2.2)、高血压1.5(95%CI，1.2~1.8)。结论在相对健康的日本中年男性中，发生MS的概率较高与血清TT水平较低有关。(C)2013年爱思唯尔公司。
OBJECTIVE To clarify the probability of low serum testosterone level as a risk factor for metabolic syndrome (MS) in middle-aged men, we measured serum total testosterone (TT) and assessed several metabolic factors because the direct risk for MS has not been investigated fully in men.METHODS This study comprised 1150 men aged >= 30 years. Physical and laboratory variables were assessed. Analyses were conducted to determine the association between serum TT level and incidence risk of MS and MS factors by a separate logistic regression model.RESULTS Mean (+/- standard deviation [SD]) serum TT level was 5.4 +/- 1.7 ng/mL in the 1150 men, and only 92 men (8.0%) were classified as having MS by the Japanese criteria. In age-adjusted analyses, higher levels of serum TT were independently associated with a lower risk of MS (odds ratio, per SD decrement of TT, 2.3; 95% confidence interval [CI], 1.7-2.9). MS risk increased by lower quintile of TT: ORs were 15.1 (95% CI, 4.6-50.0) for first quintile, 8.8 (95% CI, 2.6-29.9) for second quintile, 5.8 (95% CI, 1.7-20.5) for third quintile, and 5.0 (95% CI, 1.4-17.9) for fourth quintile compared with highest quintile of TT. Age-adjusted ORs for the incidence of dichotomous components of MS per SD decrement of TT were 1.8 (95% CI, 1.5-2.3) for waist circumference, 1.6 (95% CI, 1.1-2.2) for dyslipidemia, and 1.5 (95% CI, 1.2-1.8) for hypertension.CONCLUSION We found that higher probability of MS was associated with lower levels of serum TT level in relatively healthy middle-aged Japanese men. (C) 2013 Elsevier Inc.