Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
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发表时间：
1999
期刊：
影响因子：
56.9
通讯作者：
D. Yang;O. Chertov;S. N. Bykovskaia;Q. Chen;M. J. Buffo;J. Shogan;M. Anderson;J. M. Schröder-J.-M.-S
中科院分区：
文献类型：
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作者：
D. Yang;O. Chertov;S. N. Bykovskaia;Q. Chen;M. J. Buffo;J. Shogan;M. Anderson;J. M. Schröder-J.-M.-S
防御素通过破坏微生物的细胞质膜而有助于宿主防御。该报告显示，人β-防御素也对未成熟树突状细胞和记忆T细胞具有趋化性。人β-防御素对稳定转染表达人CCR 6的细胞具有选择性趋化性，CCR 6是一种优先由未成熟树突状细胞和记忆T细胞表达的趋化因子受体。β-防御素诱导的趋化性对百日咳毒素敏感，并被CCR 6抗体抑制。碘化LARC，CCR 6的趋化因子配体，CCR 6转染细胞的结合被β-防御素竞争性取代。因此，β-防御素可以通过与CCR 6相互作用将树突状细胞和T细胞募集到微生物入侵的位点来促进适应性免疫应答。
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.