Increased Levels of Soluble Cytokine Receptors in the Synovial Fluid of Temporomandibular Joint Disorders in Relation to Joint Effusion on Magnetic Resonance Images
Increased Levels of Soluble Cytokine Receptors in the Synovial Fluid of Temporomandibular Joint Disorders in Relation to Joint Effusion on Magnetic Resonance Images
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DOI：
10.1016/j.joms.2009.10.027
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发表时间：
2010-05-01
影响因子：
1.9
通讯作者：
Demura, Noboru
中科院分区：
文献类型：
--
作者：
Kaneyama, Keiseki;Segami, Natsuki;Demura, Noboru
目的：通过对55例颞下颌关节紊乱病(TMD)患者的关节腔积液(TMJ)进行磁共振成像，同时采集滑液标本，探讨关节积液(JE)在TMJ T2加权像上与关节液中多种可溶性细胞因子受体的相关性。乙脑的等级从0到3，0级表示没有乙脑，1级到3级表示乙脑存在。结果：30个关节滑液中细胞因子受体的平均浓度显著高于25个非关节炎组。结论：细胞因子受体水平升高可能影响JE的表达，可能在TMD的发病机制中起重要作用。这些结果也提示乙脑可能反映了TMJ的滑膜炎症。(C)2010美国口腔颌面外科协会口腔颌面外科杂志68：1088-1093,2010
Purpose: The purpose of this study is to clarify the significance of joint effusion (JE) on T2-weighted magnetic resonance images of the temporomandibular joint (TMJ) in comparison to various soluble cytokine receptors in the synovial fluid of patients with temporomandibular disorders (TMDs).Patients and Methods: Magnetic resonance imaging of 55 TMJs of 55 patients with TMD was performed, and synovial fluid samples were obtained on the same day. The grade of JE was evaluated on a scale from 0 to 3, with grade 0 indicating the absence of JE and grades 1 to 3 indicating the presence of JE. Correlations were measured between JE and the concentrations of soluble tumor necrosis factor receptors I and II, interleukin (IL) 6 soluble receptor, IL-1 soluble receptor type II, and IL-1 receptor antagonist and protein in the synovial fluid samples.Results: The mean concentrations of cytokine receptors in the synovial fluid were significantly higher in the 30 joints with JE than in the 25 joints without JE. There were no correlations between the JE grade and the level of any mediators.Conclusion: Increased levels of cytokine receptors are likely to influence the expression of JE and may play important roles in the pathogenesis of TMD. These results also suggest that JE may reflect synovial inflammation of the TMJ. (C) 2010 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 68:1088-1093, 2010