Effects of weak electric fields on the activity of neurons and neuronal networks
Effects of weak electric fields on the activity of neurons and neuronal networks
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DOI：
10.1093/oxfordjournals.rpd.a006367
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发表时间：
2003-01-01
影响因子：
1
通讯作者：
Fox, J
中科院分区：
文献类型：
--
作者：
Jefferys, JGR;Deans, J;Fox, J
施加到脑组织的电场会影响细胞特性。它们将超极化最接近电场正部分的细胞末端，并去极化最接近负部分的末端。在神经元的情况下，这会影响兴奋性。这些跨膜电位的变化如何分布取决于神经元的长度常数和它的几何形状;如果神经元是电紧凑的，跨膜电位的变化几乎成为电场方向上距离的线性函数。来自哺乳动物海马的神经元，保持在体外的组织切片中，受到大约1-5 V m（-1）的场的显著影响。
Electric fields applied to brain tissue will affect cellular properties. They will hyperpolarise the ends of cells closest to the positive part of the field, and depolarise ends closest to the negative. In the case of neurons this affects excitability. How these changes in transmembrane potential are distributed depends on the length constant of the neuron, and on its geometry; if the neuron is electrically compact, the change in transmembrane potential becomes an almost linear function of distance in the direction of the field. Neurons from the mammalian hippocampus, maintained in tissue slices in vitro, are significantly affected by fields of around 1-5 V m(-1).