Secondary leukemia after treatment with paclitaxel and carboplatin in a patient with recurrent ovarian cancer

Secondary leukemia after treatment with paclitaxel and carboplatin in a patient with recurrent ovarian cancer
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复发性卵巢癌患者接受紫杉醇和卡铂治疗后继发性白血病

DOI:
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发表时间:
2005
期刊:
International Journal of Gynecologic Cancer
影响因子:
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通讯作者:
J. Kavanagh
J. Kavanagh
中科院分区:
--
文献类型:
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作者:
H. See;D. Thomas;C. Bueso;J. Kavanagh

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骨髓增生异常综合征(MDS)或急性髓性白血病(AML)的发生已报告后,与细胞毒性烷化剂为基础的化疗治疗实体瘤。我们报告一位转移性卵巢癌患者,接受卡铂和紫杉醇治疗后,发生继发性急性红细胞白血病。在过去的十年中,III期和IV期卵巢癌患者的总体生存率有所增加。有必要监测紫杉醇和铂类药物治疗方案的长期结局,特别是监测继发性MDS和/或AML的发生。本文综述了活动性卵巢癌继发白血病的发病率和预后。
The occurrence of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) has been reported after treatment with cytotoxic alkylating agent–based chemotherapy for solid tumors. We report a patient with metastatic ovarian carcinoma treated with carboplatin and paclitaxel, who developed secondary acute erythroid leukemia. The overall survival of patients with stage III and IV ovarian cancer has increased in the past decade. Monitoring of the long-term outcome of paclitaxel- and platinum-based regimens is warranted, particularly with regard to monitoring the development of secondary MDS and/or AML. The incidence and outcome of secondary leukemia in the setting of active ovarian carcinoma is reviewed.
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