Signal control through Raf: in sickness and in health
Signal control through Raf: in sickness and in health
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DOI：
10.1038/cr.2011.193
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发表时间：
2011-12
期刊：
影响因子：
44.1
通讯作者：
Jihan K Osborne;Elma Zaganjor;M. Cobb
中科院分区：
文献类型：
--
作者：
Jihan K Osborne;Elma Zaganjor;M. Cobb
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.
