Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase
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DOI：
10.1016/j.bmcl.2006.03.009
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Sun, HB
中科院分区：
文献类型：
--
作者：
Chen, J;Liu, J;Sun, HB
油酸及其合成衍生物已被鉴定为糖原磷酸化酶的新型抑制剂。在这一系列化合物中，4（IC 50 = 3.3 μ M）是最有效的GPa抑制剂。初步的构效关系的油酸衍生物进行了讨论。(c)2006爱思唯尔有限公司保留所有权利。
Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 mu M) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed. (c) 2006 Elsevier Ltd. All rights reserved.