Periodontitis and myocardial hypertrophy
Periodontitis and myocardial hypertrophy
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牙周炎和心肌肥厚
DOI：
10.1038/hr.2016.146
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发表时间：
2017
期刊：
影响因子：
5.4
通讯作者：
Komuro I
中科院分区：
文献类型：
--
作者：
Suzuki J;Sato H;Kaneko M;Yoshida A;Aoyama N;Akimoto S;Wakayama K;Kumagai H;Ikeda Y;Akazawa H;IzumiY;Isobe M;Komuro I
心血管疾病与牙周炎之间有着密切的关系。据报道，心肌肥厚可能会影响牙周炎在临床设置。虽然这些临床观察有一些研究的局限性，他们强烈建议牙周炎的严重程度和左心室肥厚之间的直接关联。然而，心肌肥厚和牙周炎之间的详细机制尚未阐明。近年来，我们发现牙周细菌感染与心肌肥厚密切相关。在小鼠主动脉横缩窄模型中，牙周病原体伴放线菌聚集杆菌通过激活基质金属蛋白酶-2显着增强心脏肥大，而另一种病原体牙龈卟啉单胞菌（Pg）并没有加速这些病理变化。在异丙肾上腺素诱导的心肌肥大模型中，Pg通过Toll样受体-2信号传导诱导心肌肥大。从我们的研究结果和其他报道来看，调节牙周炎引起的慢性炎症可能在治疗心肌肥厚中起关键作用。本文就心肌肥厚与牙周炎的病理生理机制作一综述。
There is a deep relationship between cardiovascular disease and periodontitis. It has been reported that myocardial hypertrophy may be affected by periodontitis in clinical settings. Although these clinical observations had some study limitations, they strongly suggest a direct association between severity of periodontitis and left ventricular hypertrophy. However, the detailed mechanisms between myocardial hypertrophy and periodontitis have not yet been elucidated. Recently, we demonstrated that periodontal bacteria infection is closely related to myocardial hypertrophy. In murine transverse aortic constriction models, a periodontal pathogen, Aggregatibacter actinomycetemcomitans markedly enhanced cardiac hypertrophy with matrix metalloproteinase-2 activation, while another pathogen Porphyromonas gingivalis (Pg) did not accelerate these pathological changes. In the isoproterenol-induced myocardial hypertrophy model, Pg induced myocardial hypertrophy through Toll-like receptor-2 signaling. From our results and other reports, regulation of chronic inflammation induced by periodontitis may have a key role in the treatment of myocardial hypertrophy. In this article, we review the pathophysiological mechanism between myocardial hypertrophy and periodontitis.