Distribution and annual changes in the proportion of Streptococcus pneumoniae serotypes in Japanese adults with pneumococcal pneumonia from 2011 to 2017
Distribution and annual changes in the proportion of Streptococcus pneumoniae serotypes in Japanese adults with pneumococcal pneumonia from 2011 to 2017
复制标题
DOI：
10.1016/j.jiac.2019.07.007
复制
发表时间：
2019-11-01
影响因子：
2.2
通讯作者：
Mukae, Hiroshi
中科院分区：
文献类型：
--
作者：
Noguchi, Shingo;Yatera, Kazuhiro;Mukae, Hiroshi
2014年，日本对所有65岁的成年人实施了23价肺炎球菌多糖疫苗(PPSV23)和13价肺炎球菌结合疫苗(PCV13)的接种。我们之前澄清了在日本儿童开始接种PCV7和PCV13疫苗后肺炎链球菌肺炎患者中PCV7、PCV13和PPSV23覆盖的血清型比例的减少；然而，关于开始常规PPSV23疫苗接种后肺炎链球菌肺炎患者中肺炎链球菌血清型比例的年度变化的信息仍不清楚。我们回顾研究了2011-2017年间229例成人肺炎球菌肺炎患者的下呼吸道标本中肺炎链球菌的培养情况，并调查了肺炎链球菌血清型比例的年变化。PPSV23覆盖的血清型比例从2011年的71.4%下降到2014年的52.2%，但从2015年到2017年基本保持不变。PCV7覆盖血清型的比例从2011年的46.4%下降到2014年的4.3%；然而，这一比例从2015年开始上升，并在2017年达到20.6%。在PCV7覆盖的血清型中，19F血清型的比例从2015年到2017年有所增加。综上所述，肺炎球菌肺炎患者接种PPSV23疫苗后，PPSV23和PCV13两种血清型的比例没有明显变化。(C)2019年日本化疗学会和日本传染病协会。爱思唯尔有限公司出版。保留所有权利。
In 2014, vaccinations with 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13) were implemented in Japan for all adults aged =65 years. We previously clarified reductions in the proportions of PCV7-, PCV13-, and PPSV23-covered serotypes in patients with pneumococcal pneumonia after the initiation of PCV7 and PCV13 vaccinations for Japanese children; however, information about the annual changes in the proportion of Streptococcus pneumoniae serotypes in patients with pneumococcal pneumonia after the initiation of routine PPSV23 vaccinations remains unclear. We retrospectively studied 229 adults with pneumococcal pneumonia which S. pneumoniae was cultured from their lower respiratory tract samples between 2011 and 2017 and investigated the annual changes in the proportion of S. pneumoniae serotypes. The proportion of PPSV23-covered serotypes decreased from 71.4% in 2011 to 52.2% in 2014, but it remained essentially unchanged from 2015 to 2017. The proportions of PCV7-covered serotypes decreased from 46.4% in 2011 to 4.3% in 2014; however, this rate increased beginning in 2015 and reached 20.6% in 2017. Among the PCV7-covered serotypes, the proportion of the 19F serotype increased from 2015 to 2017. In conclusion, there were no obvious changes in the proportion of PPSV23-covered and PCV13-covered serotypes in patients with pneumococcal pneumonia after the initiation of routine PPSV23 vaccinations. (C) 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.