Cryptogenic epilepsy: An infectious etiology?
Cryptogenic epilepsy: An infectious etiology?
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DOI：
10.1046/j.1528-1157.2001.25500.x
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发表时间：
2001-03-01
期刊：
影响因子：
5.6
通讯作者：
Kasper, LH
中科院分区：
文献类型：
--
作者：
Stommel, EW;Seguin, R;Kasper, LH
目的：隐源性癫痫是一组病因不明的癫痫综合征，约占所有癫痫综合征的20%。我们选择了这一亚型癫痫的患者，用酶联免疫吸附试验检测他们弓形虫抗体的证据。在多达20%的美国人口中发现了弓形虫，这些人以潜伏的缓殖子形式形成了休眠的脑囊。我们调查了隐源性癫痫可能与隐匿性弓形虫感染有关的假设。方法：我们选择隐源性癫痫患者，用酶联免疫吸附试验检测弓形虫抗体的证据。结果：我们发现隐源性癫痫患者弓形虫抗体水平显著高于对照组[光密度(OD)增加59%，p=0.013]。在多元Logistic回归模型中调整受试者的性别和年龄后，这种相关性仍然存在，但不再具有统计学意义。结论：我们的结果表明，慢性弓形虫感染合并脑囊肿可能是隐源性癫痫的原因之一。
Purpose: Cryptogenic epilepsy, the group of epilepsy syndromes for which an etiology is unknown, comprises similar to 20% of all epilepsy syndromes. We selected patients in this subgroup of epilepsy and tested them for evidence of Toxoplasma gondii IgG antibodies by the enzyme-linked immunosorbent assay. T. gondii is found in up to 20% of the U.S. population forming dormant brain cysts in the latent bradyzoite form. We investigated the hypothesis that dormant T. gondii infection might be associated with cryptogenic epilepsy.Methods: We selected patients with cryptogenic epilepsies and tested them for evidence of T. gondii IgG antibodies by the enzyme-linked immunosorbent assay. A control group was also tested for comparison.Results: We have found a statistically-significant elevation of T. gondii antibodies among cryptogenic epilepsy patients as compared to controls [59% increase in optical density (OD), p = 0.013]. This association persisted after adjustment for subjects' gender and age in a multiple logistic regression model; however, it was no longer as statistically significant.Conclusions: Our results suggest that chronic T. gondii infection with brain cysts may be a cause of cryptogenic epilepsy.