Effect of Acute Ischemia, Nitroglycerin and Nitroprusside on Regional Myocardial Thickening, Stress and Perfusion: Experimental Echocardiographic Studies
Effect of Acute Ischemia, Nitroglycerin and Nitroprusside on Regional Myocardial Thickening, Stress and Perfusion: Experimental Echocardiographic Studies
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急性缺血、硝酸甘油和硝普钠对局部心肌增厚、应激和灌注的影响：实验超声心动图研究
DOI：
10.1161/01.cir.60.1.121
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发表时间：
1979
期刊：
影响因子：
37.8
通讯作者：
M. Marcus
中科院分区：
文献类型：
--
作者：
R. Kerber;James B. Martins;M. Marcus
本研究的目的是证明超声心动图可以显示急性缺血心肌收缩壁变薄，并比较硝酸甘油和硝普塞对缺血心肌收缩壁变薄、壁应力和灌注的影响。37只犬，冠状动脉旋闭塞术后收缩末与舒张末后壁厚度之比由1.30±0.02降至0.88:0.01 (p < 0.001)；闭塞动脉供血区灌注由98.2±7.5 ml/ 100g /min降至36.5±2.9 ml/ 100g /min （p < 0.001）。给予硝酸甘油和硝普赛可使平均动脉压分别降低7%和15%。尽管冠状动脉灌注压降低，但经壁灌注、心内膜/心外膜灌注比和收缩变薄保持不变。两种药物均可使缺血“壁应力指数”（心室压X心室直径/壁厚）降低近50%。因此，硝酸甘油和硝普塞对急性心肌缺血模型同样有益。
The purposes of this study were to demonstrate that echocardiography can be used to demonstrate the systolic wall thinning of acutely ischemic myocardium, and to compare the effects of nitroglycerin and nitroprusside on systolic thinning, wall stress and perfusion of ischemic myocardium. In 37 dogs, the ratio of end-systolic-to-end-diastolic posterior wall thickness fell from 1.30 ± 0.02 to 0.88:0.01 (p < 0.001) after circumflex coronary occlusion; perfusion of the area supplied by the occluded artery fell from 98.2 ± 7.5 ml/100 g/min to 36.5 ± 2.9 ml/100 g/min (p < 0.001). Nitroglycerin and nitroprusside were given to lower mean arterial pressure by 7% and 15%. Despite the reduction in coronary perfusion pressure, transmural perfusion, endocardial/epicardial perfusion ratio and systolic thinning remained constant. Both drugs reduced the ischemic "wall stress index" (ventricular pressure X ventricular diameter/wall thickness) by almost 50%. Thus, both nitroglycerin and nitroprusside were equally beneficial in this model of acute myocardial ischemia.