Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers
Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers
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DOI：
10.1067/mpd.2000.109149
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发表时间：
2000-12-01
影响因子：
5.1
通讯作者：
Georgieff, MK
中科院分区：
文献类型：
--
作者：
deReginer, RA;Nelson, CA;Georgieff, MK
目的：我们评估了正常新生儿（n = 32）和糖尿病母亲（IDM，n = 25）的婴儿听觉识别记忆的神经通路的完整性。IDM有胎儿代谢异常的风险，可能会损害识别记忆通路。我们假设，新生儿IDM会有识别记忆缺陷，这将与以后的认知developments.Study设计：识别记忆与事件相关电位（ERPs）进行了评估。新生儿ERPs引起的母亲的声音进行了比较，由一个陌生人的声音。Bayley婴儿发展量表在1岁时进行管理。结果：婴儿在控制和IDM组表现出识别的母亲的声音，但他们的ERP模式不同。与陌生人的声音相比，两组都表现出由母亲的声音引起的“P2”peals的幅度和潜伏期增加。在对照组中，陌生人的声音也引起了负的慢波，这在IDM中被衰减。负性慢波与1年的智力发育指数显着相关。结论：一个特定的新生儿ERP模式的存在下，表明更好的1年的认知发展在婴儿中的控制和I DM组。来自IDM的ERPs表现出识别记忆障碍的微妙证据。
Objectives: We evaluated the integrity of neural pathways for auditory recognition memory in normal newborn infants (n = 32) and infants of diabetic mothers (IDMs, n = 25). IDMs are at risk for fetal metabolic abnormalities that potentially damage recognition memory pathways. We hypothesized that newborn IDMs would have recognition memory deficits that would be correlated with later cognitive development.Study design: Recognition memory was assessed with event-related potentials (ERPs). Neonatal ERPs elicited by the maternal voice were compared with those elicited by a stranger's voice. The Bayley Scales of Infant Development were administered at 1 year of age.Results: Infants in both the control and IDM groups demonstrated recognition of the maternal voice, but their ERP patterns differed. Both groups demonstrated increased amplitude and latency for the "P2" peals elicited by the maternal voice compared with the stranger's voice. In the control group the stranger's voice also elicited a negative slow wave, which was attenuated in the IDMs. The negative slow wave correlated significantly with the l-year Mental Developmental Index.Conclusions: The presence of a specific neonatal ERP pattern indicated better 1-year cognitive development in infants in the control and I DM groups. ERPs from IDMs demonstrated subtle evidence of recognition memory impairments.