COMBINED MODALITY TREATMENT WITH LOW-DOSE RADIATION AND MOPP CHEMOTHERAPY FOR CHILDREN WITH HODGKINS-DISEASE
COMBINED MODALITY TREATMENT WITH LOW-DOSE RADIATION AND MOPP CHEMOTHERAPY FOR CHILDREN WITH HODGKINS-DISEASE
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DOI：
10.1200/jco.1987.5.5.742
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发表时间：
1987-05-01
影响因子：
45.3
通讯作者：
LINK, MP
中科院分区：
文献类型：
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作者：
DONALDSON, SS;LINK, MP
对霍奇金病儿童进行高剂量放射治疗可能与软组织和骨生长的长期改变有关。为了尽量减少这种并发症，我们在新诊断的病理分期的霍奇金病儿童中采用低剂量放疗联合6个周期的MOPP（氮芥、长春新碱、甲基苄肼、泼尼松）化疗。在55名接受这种治疗的儿童中，精算生存率和无复发率分别为89%和90%，中位随访时间为7 1/2年，最长随访时间为15 1/2年。局部控制率为97%。当使用较低剂量的辐射时，以前遇到的生长变化没有发生。然而，三个孩子患上了急性白血病。这项研究表明，绝大多数儿童霍奇金病可以治愈的综合治疗。这一经验提供了长期的随访，因此作为新的正在进行的协议的基础上使用低剂量涉及领域的辐射与新的药物组合。
High doses of radiation administered to children with Hodgkin''s disease may be associated with long-term alterations in soft tissue and bone growth. In an attempt to minimize this complication, we initiated a protocol using low doses of radiation in conjunction with six cycles of MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) chemotherapy in newly diagnosed, pathologically staged children with Hodgkin''s disease. Of 55 children treated in this fashion, the actuarial survival and freedom from relapse rates are 89% and 90%, respectively, with median follow-up of 7 1/2 years and maximum follow-up of 15 1/2 years. The local control rate is 97%. The previously encountered growth alteration did not occur when lower doses of radiation were used. However, three children developed acute leukemia. This study demonstrates that the vast majority of children with Hodgkin''s disease can be cured with combined modality therapy. This experience provides long-term follow-up and thus serves as the basis for new ongoing protocols using low-dose involved field radiation with new drug combinations.