Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa
Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa
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DOI：
10.1016/s0006-3223(00)01013-1
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发表时间：
2001-04-01
影响因子：
10.6
通讯作者：
Deep, D
中科院分区：
文献类型：
--
作者：
Kaye, WH;Nagata, T;Deep, D
Background: Anorexia nervosa is an often chronic disorder with high morbidity and mortality Many people relapse after weight restoration. This study was designed to determine whether a selective serotonin reuptake inhibitor would improve outcome and reduce relapse after weight restoration by contributing to maintenance of a healthy normal weight and a reduction of symptoms.Methods: We administered a double-blind placebo-controlled trial of fluoxetine to 35 patients with restricting-type anorexia nervosa. Anorexics were randomly assigned to fluoxetine (n = 16) or a placebo (n = 19) after inpatients weight gain and then were observed as outpatients for 1 year.Results: Ten of 16 (63%) subjects remained on fluoxetine for a year, whereas only three of 19 (16%) remained on the placebo for a year (p = .006). Those subjects remaining on fluoxetine for a year had reduced relapse as determined by a significant increase in weight and reduction in symptoms.Conclusions: This study offers preliminary evidence that fluoxetine may be useful improving outcome and preventing relapse of patients with anorexia nervosa after weight restoration. Biol Psychiatry 2001;49:644-652 (C) 2001 Society of Biological Psychiatry.
