Worsened punch sticking by external lubrication with magnesium stearate
Worsened punch sticking by external lubrication with magnesium stearate
复制标题
硬脂酸镁外部润滑导致冲头粘着恶化
DOI：
10.1016/j.ijpharm.2023.123636
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发表时间：
2024
影响因子：
5.8
通讯作者：
Sun, Changquan Calvin
中科院分区：
文献类型：
--
作者：
Xiang, Tianyi;Sun, Changquan Calvin
使用硬脂酸镁 (MgSt) 对工具进行外部润滑是在压缩具有高粘附倾向的粉末（例如许多纯活性药物成分 (API)）时消除冲头粘附的常见策略。我们发现，这实际上会导致在低压实压力下加剧冲头粘连。这种违反直觉的现象是根据冲头尖端、MgSt 和 API 之间力的相互作用来解释的。观察到的 API 压力和机械性能对这一现象的影响支持了这一解释。
External lubrication of tooling with magnesium stearate (MgSt) is a common strategy to eliminate punch sticking when compressing powders with a high sticking propensity, such as many pure active pharmaceutical ingredients (APIs). We found that it actually led to aggravated punch sticking at low compaction pressures. This counterintuitive phenomenon was explained based on interplay of forces among the punch tip, MgSt, and API. The explanation is supported by the observed effects of pressure and mechanical properties of APIs on this phenomenon.