Synaptic differences in the patch matrix compartments of subjects with schizophrenia: a postmortem ultrastructural study of the striatum.
Synaptic differences in the patch matrix compartments of subjects with schizophrenia: a postmortem ultrastructural study of the striatum.
复制标题
精神分裂症患者斑块基质区室的突触差异：纹状体死后超微结构研究。
DOI：
10.1016/j.nbd.2005.03.015
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发表时间：
2005
影响因子：
6.1
通讯作者：
Conley,RobertR
中科院分区：
文献类型：
--
作者：
Roberts,RosalindaC;Roche,JoyK;Conley,RobertR
纹状体处理运动、认知和边缘系统电路。纹状体斑块和基质室的组织在许多方面不同，包括连接。在任何一个隔室中的脱落都可能产生不同的功能后果。本研究比较了精神分裂症患者（SZ，n = 14）与正常对照组（NC，n = 8）的斑片和基质中的突触组织。死后纹状体组织进行钙结合蛋白免疫细胞化学，以确定补丁与基质室，准备电子显微镜，并使用体视学分析。与NC相比，在SZ受试者中观察到几种突触变化，包括在典型抗精神病药物的SZ病例中壳核补丁（高44%）和尾状核基质（高36%）中皮质型突触密度更高。这些变化似乎是正常的，而不是由给药引起的。异常连接可能代表正常突触修剪的失败，并可能在精神分裂症的边缘系统或认知功能障碍中发挥作用。
The striatum processes motor, cognitive, and limbic circuitry. Striatal patch and matrix compartments are organized differently in many aspects including connectivity. Abnormalities in either compartment could have different functional consequences. The present study compares the synaptic organization in the patches and matrix in subjects with schizophrenia (SZ, n = 14) versus normal controls (NC, n = 8). Postmortem striatal tissue was processed for calbindin immunocytochemistry to identify the patch versus matrix compartments, prepared for electron microscopy, and analyzed using stereology. Several synaptic changes were observed in the SZ subjects vs. NCs including a higher density of cortical-type synapses in the putamen patch (44% higher) and in the caudate matrix (36% higher) in SZ cases on typical antipsychotic drugs. These changes appeared to be normalized rather than caused by treatment. The abnormal connectivity may represent a failure of normal synaptic pruning and may play a role in limbic or cognitive dysfunction in schizophrenia.