Alan Poland, MS, MD: 1940-2020 Poisons as Probes of Biological Function.
Alan Poland, MS, MD: 1940-2020 Poisons as Probes of Biological Function.
复制标题
艾伦·波兰，MS，MD：1940-2020 毒物作为生物功能的探针。
DOI：
10.1021/acs.chemrestox.0c00159
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发表时间：
2021
影响因子：
4.1
通讯作者：
Wilson,RachelH
中科院分区：
文献类型：
--
作者：
Avilla,MeleN;Bradfield,ChristopherA;Glover,Ed;Hahn,MarkE;Malecki,KristenMC;Stern,PaulaH;Wilson,RachelH
We lost a great scientific mind on February 20, 2020 with the passing of Alan Poland. Alan’s work represents one of the most significant achievements in modern toxicology, the discovery of the Ah receptor and its role in the toxic mechanism of halogenated dioxins and dibenzofurans. His pioneering work, employing these highly toxic molecules as molecular probes of biological function, opened the door to a larger understanding of how animals adapt metabolically to changing chemical and physical environments. Through his foundational research, scientific leadership, and mentoring, we also have greater insights into circadian rhythms, hypoxia signal transduction, and the regulation of xenobiotic metabolism.After graduation from Rensselaer Polytechnical Institute in 1961, Alan went on to medical school at the University of Rochester where he spent a year (1963− 1964) doing research in the laboratory of Lawrence G. Raisz of the Department of Pharmacology. Larry Raisz was an endocrinologist with an illustrious career in bone metabolism and an early and important influence on Alan’s professional life. The Medical School had a program that allowed medical students to take a year off to learn how to carry out research. Alan worked on developing a radioimmunoassay for parathyroid hormone (PTH), and this success produced his first publication:“Hormone Synthesis and Secretion by Rat Parathyroid Glands
