Local and long-range functional connectivity is reduced in concert in autism spectrum disorders
Local and long-range functional connectivity is reduced in concert in autism spectrum disorders
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DOI：
10.1073/pnas.1214533110
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发表时间：
2013-02-19
影响因子：
11.1
通讯作者：
Kenet, Tal
中科院分区：
文献类型：
--
作者：
Khan, Sheraz;Gramfort, Alexandre;Kenet, Tal
远端皮质功能连通性在自闭症谱系障碍（ASD）中经常降低，但ASD中局部皮质功能连通性的性质仍然是难以捉摸的。我们使用脑磁图来测量与任务相关的局部功能连通性，这体现在被诊断为ASD的个体和正常发育的个体在观察中性面孔、情绪面孔和房屋时梭状面区（FFA）的α振荡相位和γ振荡振幅之间的耦合。在相同的模式下，我们还测量了FFA和皮层其他部分之间与任务相关的远程功能连接。与早期的研究一致，ASD组FFA与三个远端皮质区域之间的远程功能连接减少。然而，与该领域的主流假设相反，我们发现ASD患者在观看人脸时，FFA内的局部功能连接也减少了。此外，两组的远程功能连接强度与局部功能连接强度直接相关；因此，远程和局部连接在ASD组中成比例地减少。最后，局部功能连通性的大小与ASD的严重程度相关，使用局部和远程功能连通性数据的统计分类识别ASD诊断的准确率为90%。这些结果表明，在皮层区域内和跨皮质区域内未能充分携带神经元集合可能是ASD的特征。
Long-range cortical functional connectivity is often reduced in autism spectrum disorders (ASD), but the nature of local cortical functional connectivity in ASD has remained elusive. We used magnetoencephalography to measure task-related local functional connectivity, as manifested by coupling between the phase of alpha oscillations and the amplitude of gamma oscillations, in the fusiform face area (FFA) of individuals diagnosed with ASD and typically developing individuals while they viewed neutral faces, emotional faces, and houses. We also measured task-related long-range functional connectivity between the FFA and the rest of the cortex during the same paradigm. In agreement with earlier studies, long-range functional connectivity between the FFA and three distant cortical regions was reduced in the ASD group. However, contrary to the prevailing hypothesis in the field, we found that local functional connectivity within the FFA was also reduced in individuals with ASD when viewing faces. Furthermore, the strength of long-range functional connectivity was directly correlated to the strength of local functional connectivity in both groups; thus, long-range and local connectivity were reduced proportionally in the ASD group. Finally, the magnitude of local functional connectivity correlated with ASD severity, and statistical classification using local and long-range functional connectivity data identified ASD diagnosis with 90% accuracy. These results suggest that failure to entrain neuronal assemblies fully both within and across cortical regions may be characteristic of ASD.