Phytophthora sojae effectors orchestrate warfare with host immunity
Phytophthora sojae effectors orchestrate warfare with host immunity
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大豆疫霉效应子与宿主免疫协调战争
DOI：
10.1016/j.mib.2018.01.008
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发表时间：
2018
影响因子：
5.4
通讯作者：
Yuanchao Wang
中科院分区：
文献类型：
--
作者：
Yan Wang;Yuanchao Wang
摘要：大豆疫霉在侵染过程中，作用于质外体或寄主细胞内的秘密效应物。它进化出诱饵来保护致病效应物免受寄主抑制。效应器通过操纵寄主靶标来干扰寄主的各种进程。效应器在对抗寄主免疫中起主要作用。大豆疫霉是危害大豆的植物病原菌之一。为了帮助与寄主建立兼容的相互作用，大豆疫霉部署了许多分泌的效应器。这些效应器要么作用于质外体空间以应对敌对条件，要么作用于宿主细胞内部以重新编程有利于病原体生长的宿主生理。效应器已被用作分子探针，在疫霉中发现效应器通过操纵宿主靶标来执行其毒力功能。此外，最近的研究还发现了疫霉中的假效应器，它作为诱饵来保护致病效应器免受寄主防御，这是植物与病原菌相互作用的一种新范式。
HighlightsPhytophthora secrets effectors acting in the apoplast or inside of host cells during infection.Phytophthora evolved decoys to shield virulent effectors from host inhibition.Effectors interfere with various host processes by manipulating host targets.Effectors constitute a major player in counteracting host immunity.Phytophthora sojae is one of the most damaging plant pathogens of soybean. To aid establishment of a compatible interaction with its host, P. sojae deploys many secreted effectors. These effectors act either in the apoplastic space to cope with hostile conditions or inside of host cells to reprogram host physiology favoring pathogen growth. Effectors have been used as molecular probes, which revealed in Phytophthora that effectors execute their virulence function via manipulating host targets. In addition, recent studies have discovered ‘pseudo-effectors’ in Phytophthora that act as decoys to shield virulence effectors from host defense, a new paradigm in plant-pathogen interactions.