Simultaneous spectrophotometric estimation of aceclofenac and paracetamol in tablet dosage form
Simultaneous spectrophotometric estimation of aceclofenac and paracetamol in tablet dosage form
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片剂剂型中醋氯芬酸和扑热息痛的同时分光光度法测定
DOI：
10.4103/0250-474x.33161
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发表时间：
2007
影响因子：
0.5
通讯作者：
BS Kuchekar
中科院分区：
文献类型：
--
作者：
P. Mahaparale;JN Sangshetti;BS Kuchekar
本文介绍了三种简便、准确、经济的同时测定片剂中醋氯芬酸和对乙酰氨基酚含量的方法：多组分法、双波长法和曲线下面积联立方程法。醋氯芬酸和对乙酰氨基酚在用玻璃双蒸水稀释的甲醇中的最大吸收分别为274.5 nm和244 nm。醋氯芬酸和对乙酰氨基酚的浓度分别在2-20 mg/ml和5-40 mg/ml范围内符合比尔定律。该方法允许快速准确地分析二元药物制剂。三种方法的结果进行了验证统计学和回收率的研究，发现是令人满意的。
Three simple, accurate and economic methods; multicomponent, two wavelength and simultaneous equations using area under curve have been described for the simultaneous estimation of aceclofenac and paracetamol in tablet dosage form. Absorption maxima of aceclofenac and paracetamol in methanol diluted with glass double distilled water was found to be 274.5 nm and 244 nm, respectively. Beer's law was obeyed in the concentration range 2-20 mg/ml for aceclofenac and 5-40 mg/ml for paracetamol. The methods allow rapid analysis of binary pharmaceutical formulation with accuracy. Results of three methods were validated statistically and by recovery studies and were found to be satisfactory.