High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia
High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia
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DOI：
10.1016/j.leukres.2013.10.016
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Chi, Hyun-Sook
中科院分区：
文献类型：
--
作者：
Ko, Sun-Young;Park, Chan-Jeoung;Chi, Hyun-Sook
关于CXCR4和VLA-4在ALL中的预后意义的数据有限。特别是，在成人和儿童ALL患者的诊断时，还没有对vla4进行评估。我们通过流式细胞术前瞻性地分析了54例新诊断为ALL的患者（29例成人，25例儿童，22例成人，24例儿童）中VLA-4和CXCR4的表达。成人和儿童急性淋巴细胞白血病患者的VLA-4和CXCR4表达水平无差异。成人高表达的CXCR4和低表达的vsa -4均与较差的预后相关；CXCR4高表达患者的无病生存期（p =0.01）和总生存期（p = 0.04）较短，VLA-4低表达患者的无病生存期较短（p = 0.02）。CXCR4和vla4的表达水平不能预测儿童患者的预后。分析成人ALL诊断时CXCR4和VLA-4的表达可以为患者预后提供有用的信息。(C) 2013 Elsevier Ltd.版权所有。
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p =0.01) and overall survival (p = 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p = 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis. (C) 2013 Elsevier Ltd. All rights reserved.