One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation.
One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation.
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DOI：
10.1038/s41598-017-01374-3
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发表时间：
2017-04-28
影响因子：
4.6
通讯作者：
Monteux C
中科院分区：
文献类型：
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作者：
Dupré de Baubigny J;Trégouët C;Salez T;Pantoustier N;Perrin P;Reyssat M;Monteux C
生物相容微胶囊在药物、化妆品和农用化学等领域的活性物质靶向输送方面具有广泛的应用价值。通过聚合物在界面上自组装获得的胶囊能够结合对刺激的响应性、生物兼容性和扩大生产。在这里，我们提出了一种一步法制备油-水界面原位膜的方法，该方法是基于聚合物在油和水相中氢键受体和给体之间的氢键络合作用。这一稳健的过程是通过不同的方法实现的，获得不同尺寸的胶囊，从使用微流体或转子-定子乳化的微米级到使用滴滴的厘米级。聚合物层具有独特的自愈和pH响应特性。在pH = 3时，膜具有粘弹性，随着pH的逐渐升高，膜变软，最终在pH = 6以上溶解，释放油相。这种一步法制备法为大批量生产功能胶囊铺平了道路。
Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.