Common variants in SIRT1 and human longevity in a Chinese population.
Common variants in SIRT1 and human longevity in a Chinese population.
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SIRT1 的常见变异与中国人群的人类寿命
DOI：
10.1186/s12881-016-0293-3
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发表时间：
2016-04-18
影响因子：
--
通讯作者：
Cai W
中科院分区：
文献类型：
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作者：
Lin R;Yan D;Zhang Y;Liao X;Gong G;Hu J;Fu Y;Cai W
研究背景：SIR 2/SIRT 1基因在酵母、蠕虫、果蝇和啮齿类动物等多种模式生物中被证实具有调节寿命的功能。SIRT 1是SIR 2的人类同源基因，被认为是人类预期寿命的候选基因。方法：在目前的研究中，我们包括616名长寿个体和846名匹配的年轻对照，以调查8种常见的单核苷酸多态性（SNP）（即，rs 12778366、rs3758391、rs3740051、rs33957861、rs7896005、rs 12413112、rs 11599176和rs 4746720）与人类寿命的关系。这8个SNPs具有较强的连锁不平衡（LD），其特征在于4个常见的单倍型，捕获99.3%，我们没有发现SIRT 1单核苷酸多态性与等位基因寿命之间存在统计学显著关联的证据，基因型或单倍型水平。结论：目前的研究结果表明，SIRT 1的几种常见变体与人类寿命无关。
Background:The silent information regulator SIR2/SIRT1gene has been demonstrated as regulating lifespan in many model organisms, including yeast, worms, fruit flies and rodents. SIRT1, the human homolog of SIR2, is considered a candidate gene as a modifier of human life expectancy.Methods:In the current study we included 616 long-lived individuals and 846 matched younger controls to investigate associations between 8 common single nucleotide polymorphisms (SNPs) (i.e., rs12778366, rs3758391, rs3740051, rs33957861, rs7896005, rs12413112, rs11599176 and rs4746720) in the SIRT1 gene and human longevity.Results:The 8 SNPs had strong linkage disequilibrium (LD) and were in an LD block, which was characterized by 4 common haplotypes that capture 99.3% of the genetic variation present within it. We found no evidence for statistically significant associations between the tested SIRT1 SNPs and longevity at the allele, genotype or haplotype levels.Conclusions:Current findings show that several common variants in SIRT1 are not associated with human longevity.