The dual role of the contact system in bacterial infectious disease
The dual role of the contact system in bacterial infectious disease
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DOI：
10.1160/th07-01-0051
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发表时间：
2007-09-01
影响因子：
6.7
通讯作者：
Herwald, Heiko
中科院分区：
文献类型：
--
作者：
Frick, Inga-Maria;Bjorck, Lars;Herwald, Heiko
止血是一个敏感而受严格调控的过程，涉及血管内皮和血细胞，以及凝血和纤溶级联因子。在过去的四十年中，越来越多的证据表明，在感染过程中，来自微生物和/或宿主的炎症介质能够调节宿主促凝和抗凝状态之间的平衡。根据激活模式的不同，这些变化可引起局部或全身性炎症反应，这可能对人类宿主有益或有害。本综述旨在介绍接触系统（也称为内在凝血途径或激肽/激肽系统）在先天免疫和全身炎症反应中的作用的最新进展。
Hemostasis is a sensitive and tightly regulated process, involving the vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. Over the last four decades evidence has accumulated that during infection, inflammatory mediators from the microbe and/or host are capable to modulate the equilibrium between the procoagulant and anticoagulant status of the host. Dependent on the mode of activation, these changes can cause either local or systemic inflammatory reactions that may be beneficial or deleterious to the human host. The present review aims to present the state of the art with respect to the role of the contact system (also known as the intrinsic pathway of coagulation or the kallikrein/kinin system) in innate immunity and systemic inflammatory reactions.