A magnetic protein biocompass
A magnetic protein biocompass
复制标题
DOI：
10.1038/nmat4484
复制
发表时间：
2016-02-01
期刊：
影响因子：
41.2
通讯作者：
Xie, Can
中科院分区：
文献类型：
--
作者：
Qin, Siying;Yin, Hang;Xie, Can
动物能探测到地球磁场的观点曾经被嘲笑过，但现在得到了充分的证实。然而，这种磁感应现象的生物学性质仍然未知。在这里，我们报告了一个假定的磁受体（果蝇CG8198，这里命名为MagR）和一个多聚体磁感棒样蛋白复合物，通过理论假设和全基因组筛选鉴定，并通过细胞、生化、结构和生物物理方法进行了验证。该磁感应复合物由已知的假定磁感受器和已知的磁感受器相关光感受器隐色素（Cry）组成，具有Cry和铁基系统的属性，并在包括地球磁场在内的磁场中表现出自发排列。这种蛋白质复合物可能构成动物磁感受的基础，并可能导致在多个领域的应用。
The notion that animals can detect the Earth's magnetic field was once ridiculed, but is now well established. Yet the biological nature of such magnetosensing phenomenon remains unknown. Here, we report a putative magnetic receptor (Drosophila CG8198, here named MagR) and a multimeric magnetosensing rod-like protein complex, identified by theoretical postulation and genome-wide screening, and validated with cellular, biochemical, structural and biophysical methods. The magnetosensing complex consists of the identified putative magnetoreceptor and known magnetoreception-related photoreceptor cryptochromes (Cry), has the attributes of both Cry- and iron-based systems, and exhibits spontaneous alignment in magnetic fields, including that of the Earth. Such a protein complex may form the basis of magnetoreception in animals, and may lead to applications across multiple fields.