An experimentally-induced acute hepatic failure model in various strains of mice
An experimentally-induced acute hepatic failure model in various strains of mice
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不同品系小鼠实验诱导的急性肝衰竭模型
DOI：
10.1007/bf02773878
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
I. Yano
中科院分区：
文献类型：
--
作者：
Y. Mizoguchi;H. Kuboi;H. Tsutsui;S. Seki;Kenzo Kobayashi;Sukeo Yamamoto;S. Morisawa;I. Yano
BALB/cAJcl小鼠经静脉注射热杀痤疮丙酸杆菌（P. acnes）， 7天后静脉注射脂多糖（LPS），肝组织大量坏死，大部分小鼠在LPS注射后24小时内死亡。利用该实验模型，研究了不同品系小鼠急性肝衰竭的反应差异。结果，与BALB/cAJcl小鼠一样，BALB/cAJcl -nu、AKR/J、C3H/HeNJcl、C57BL/6NJcl和DDy小鼠也可诱导急性肝衰竭。然而，作为一个例外，C3H/HeJ小鼠几乎没有肝细胞坏死，存活率非常高，因为C3H/HeJ小鼠在遗传上对LPS刺激没有反应。这些结果表明，对于这种实验性诱导急性肝衰竭，巨噬细胞必须通过两步刺激p激活。acnesand有限合伙人。
When BALB/cAJcl mice are intravenously injected with heat-killedPropionibacterium acnes (P. acnes)followed by an intravenous injection of lipopolysaccharide (LPS) 7 days later, massive necrosis is induced in the liver tissue and most of the mice die within 24 hours of LPS injection. Using this experimental model, acute hepatic failure was induced in various strains of mice and the difference in the response was studied. As a result, as in BALB/cAJcl mice, acut hepatic failure was also induced in BALB/ cAJcl-nu, AKR/J, C3H/HeNJcl, C57BL/6NJcl and DDy mice. However, as an exception, hepatic cell necrosis was hardly seen and the survival rate was remarkable high in C3H/HeJ mice, which genetically do not respond to LPS stimulation. These results indicate that for this experimental induction of acute hepatic failure, macrophages must be activated by the two-step stimulation ofP. acnesand LPS.