Tools of the Trade in Vaccine Design
Tools of the Trade in Vaccine Design
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DOI：
10.1126/science.290.5499.2074b
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发表时间：
2000-12
期刊：
影响因子：
56.9
通讯作者：
A. Sette
中科院分区：
文献类型：
--
作者：
A. Sette
Michael Hagmann在他的新闻文章“Computers aid vaccine design”中很好地描述了计算机算法和计算机建模预测抗原的哪些部分（哪些表位）最有可能引发强烈的免疫应答，因此非常适合作为疫苗的靶标的潜力（特刊，Frontiers in Cellular Immunology，10月6日，第80页）。这项令人兴奋的技术无疑将为癌症和传染病提供重要的免疫治疗。然而，在这篇文章中，我们希望澄清一些不准确的地方：首先，Hagmann说，德国蒂宾根大学的Hans-Georg Rammensee定义了主要组织相容性复合体（MHC）I类蛋白的基序，我们的小组也对MHC II类蛋白的表位做了同样的定义。但事实上，两个小组都定义了两种类型的基序，并编译了I类和II类数据库。
Michael Hagmann provides a good account in his News article “Computers aid vaccine design” of the potential that computer algorithms and computer modeling have for predicting what parts of an antigen (what epitopes) would be most likely to elicit a strong immunological response and hence be well suited as a target for vaccines (special issue, Frontiers in Cellular Immunology, 6 Oct., p. 80). This exciting technology will undoubtedly yield important immunotherapeutics for both cancer and infectious diseases. In the article, however, there are a few inaccuracies that we wish to clarify.First, Hagmann says that Hans-Georg Rammensee at the University of Tübingen, Germany, defined motifs for major histocompatibility complex (MHC) class I proteins, and our group did the same for epitopes for MHC class II proteins. But, in fact, both groups defined both types of motifs and compiled class I and class II databases.